Microbiology- Antibiotic Therapy

Question 1

Bacteriostatic antibiotic

Answer 1

Inhibits bacteria growth

Question 2

Bactericidal

Answer 2

Kill bacteria

Question 3

Antibiotics

Answer 3

A drug used to treat/ prevent infection caused by microorganisms

Question 4

Ideal antibiotic

Answer 4

Selective toxicity
Vidal
Long Half life
Good tissue distribution
No side effects/ adverse drug reactions
Oral and parenteral preparations

Question 5

Targets of Beta-Lactams

Answer 5

Penicillin Binding Proteins

Question 6

What antibiotic is used for gram positive organisms only?

Answer 6

Flucloxacilin

Question 7

What antibiotic is used for gram positive and negative organisms?

Answer 7

Amoxicillin, Coamoxiclav

Question 8

What antibiotic is used from gram negative organisms

Answer 8

Temocillin (IV)

Question 9

Why is cephalosporins very rarely used now

Answer 9

It kills off normal gut bacteria, allowing C-diff to overgrow-> gastroenteritis

Question 10

Non beta lactam antibiotic

Answer 10

Glycopeptides, which have no activity against gram negative organisms

Question 11

How do antibiotics inhibit protein synthesis?

Answer 11

Attach to bacterial ribosomes (structurally different from mammalian ribosomes)

Eg gentamicin, erythromycin

Antibiotics are mainly bacteriostatic (except aminoglycosides)

Question 12

What toxins do gram positive organisms produce?

Answer 12

Exotoxins