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MEDICINAL CHEMISTRY > MEDICINAL CHEMISTRY > Flashcards

MEDICINAL CHEMISTRY Flashcards

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1
Q

OPIATE RECEPTOR

A

mu ,kappa ,sigma ,delta ,epislon

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2
Q

endogenous peptides

A

enkephalin
endorphine
dynorphine

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3
Q

Classification of sympathomimetic

A

direct acting
indirect acting
mixed acting

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4
Q

classification of direct acting sympathomimetics

A

endogenous catecholamines
alpha agonist
beta agonist
dual alpha and beta agonist/antagonist

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5
Q

examples of endogenous catecholamines

A

dopamine
epinephrine
norepinephrine

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6
Q

examples of alpha agonist

A

phenylethanolamines
aryl imidazoline
methyldopa
aminoimidazoline

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7
Q

examples of beta agonist

A

isoprenaline
resorcinol bronchodilators (terbutaline , metaproterenol)
albuterol
salmeterol

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8
Q

dual alpha and beta agonist/antagonist

A

dobutamine

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9
Q

indirect acting sympathomimetics

A

pseudoephedrine
amphetamine
methamphetamine

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10
Q

mixed acting sympathomimetic

A

ephedrine

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11
Q

location of nicotinic receptors

A

NM -present in skeletal muscles endplate

NN -present in ganglionic cells , spinal cord ,adrenal medullary cells , certain area of the brain

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12
Q

stimulants of nicotinic receptors

A

NM - phenyl trimethyl ammonium

NN- dimethyl phenyl piperazine

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13
Q

nicotinic receptor blockers

A

NM - tubocurarine

NN -hexamethonium

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14
Q

muscarinic receptor blockers /antagonist

A

atropine

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15
Q

prototype agonist of muscarinic receptor

A

muscarine ;its obtained from amantia muscaria

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16
Q

location of muscarinic receptors

A

M1 -nervous system , gastric gland

M2 - heart , smooth muscles

M3 - smooth muscles of blood vessels and lungs ,glands

M4 - CNS ,heart

M5 -CNS

17
Q

classification of parasympathomimetic agents

A

DIRECT ACTING
1 choline esters
2 cholinomimetic alkaloids -natural alkaloids
-synthetic alkaloids
INDIRECT ACTING
1 reversible
2 irreversible

18
Q

examples of choline esters

A

carbachol chloride
acetylcholine chloride
methacholine chloride
bethanechol chloride

19
Q

examples of natural alkaloids

A

pilocarpine
muscarine
arecoline

20
Q

examples of synthetic alkaloids

A

aceclidine

oxotremorine

MEDICINAL CHEMISTRY (1 decks)

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