Mast Cell Tumors Flashcards
What is the most common cutaneous neoplasm in the dog
mast cell tumor
what is the most common cutaneous neoplasm in the cat?
basal cell tumor
what are the two primary stains used in the cytologic diagnosis of MCTs?
geimsa, toluidine blue
what do the granules of MCTs contain?
heparin, histamine, TNF-a (tumor necrosis factor alpha), proteases
what % of cutaneous tumors in the dog are MCTs?
16-21%
what dog breeds are at increased risk for MCTs?
brachycephalics (boxer, boston terrier, english bulldog, pug), labrador retrievers, golden retrievers, cocker spaniels, schnauzers, staffordshire terriers, beagles, rhodesian ridgebacks, weimaraners, and chinese shar-pei
what dog breeds are typically associated with less biologically aggressive MCTs?
brachycephalics
what dog breeds are typically associated with more biologically aggressive MCTs?
chinese shar-pei
what percent of intermediate-to-high grade MCTs in dogs are associated with c-kit mutations?
25-30% (approximately 1/4 to 1/3)
what percent of dogs present with multiple mast cell tumors?
11-14%
what is the name of the phenomenon associated with erythema and wheal formation in surrounding tissues following mechanical manipulation of MCTs?
darier’s sign
what anatomic locations are associated higher-grade MCTs and worse prognosis?
mucous membrane sites and subungual tumors
what anatomic location of MCTs is associated with a better prognosis?
subcutaneous tumors
what are AgNORs?
Argyrophilic nucleolar organizer regions
what is the metastatic rate for undifferentiated (high grade) MCTs in dogs?
55-96%
