Malabsorption Disease inc. Coeliac

Question 1

In Coeliac disease what does the body have an adverse reaction to?

Answer 1

Gluten breakdown products - gliadins

Question 2

What two anti-bodies are produced in coeliac disease?

Answer 2

anti-gliadin and anti-endomsial

Question 3

What does anti-endomysial antibody break down?

Answer 3

Tissue Tranglutaminase

Question 4

What does the enzyme tissue transglutaminase do?

Answer 4

Breaks down gluten

Question 5

What happens histologically to the wall of the small intestine?

Answer 5

atrophy of villi and hypertrophy of crypts

Question 6

Which part f the GI tract is most affected in coeliac disease?

Answer 6

The proximal small intetsine

Question 7

What are the symptoms of coeliac disease?

Answer 7

anaemic symptoms
nausea / vomitting
Diahorrea

Question 8

How would you investigate for Coeliac Disease? (3)

Answer 8

Anti-TtG antibodies
endoscopy
biopsy and histology for atrpy of villi and hypertrophy of crypts

Question 9

What are the complications which can arise from coeliac disease?

Answer 9

Calcium Malabsorption - osteopenia, osteoporosis, cerebellar dysfunction

Inc risk of malignancy

Question 10

What is the treatment for coeliac disease?

Answer 10

Gluten free diet`