M1 blood storage Flashcards
Recommended sodium phosphate.
BRAXTON HICKS (1868)
Performed direct transfusion.
ALEXIS CARREL (1908)
Sodium Citrate was used as an anticoagulant solution for transfusions.
HUSTIN (1914)
What anticoagulant did Hustin (1914) discovered?
Sodium Citrate
What anticoagulant did Braxton Hicks (1868) discovered?
Sodium Phosphate
Determined the minimum amount of sodium citrate needed for anticoagulation and demonstrated its nontoxicity.
LEWISOHN (1915)
Introduced a citrate-dextrose solution for the preservation of blood.
ROUS & TURNER (1916)
What used for blood preservation with glucose.
Acid-Citrate-Dextrose (ACD)
It helps preserve the viability of blood because it serves as an additional source of nutrients for the cell.
Glucose
The year of the first blood bank was established in a Leningrad hospital
1932
He established the first hospital blood bank in the United States.
BERNARD FANTUS (1937)
Discovered the Rh blood group system
LANDSTEINER, WEINER, LEVINE AND STETSON (1939-1940)
He pioneered the works of blood preservation research during the war.
Dr. Charles Drew
Appointed director of the 1st American Red Cross Blood Bank at Presbyterian Hospital
DR. CHARLES DREW (FEBRUARY 1941)
Introduced the formula for the preservative Acid-Citrate Dextrose (ACD) to be used instead of sodium citrate.
LOUTIT AND MOLLISON OF ENGLAND (1943)
AUDREY SMITH (1950)
Reported the use of glycerol cryoprotectant for freezing red blood cells
RBC freezing can help store rare blood line up to 10 years
Glycerol Cryoprotectant
Introduced an improved preservative solution, Citrate-Phosphate-Dextrose (CPD) which was less acidic and eventually replaced Acid-Citrate Dextrose (ACD) as the standard preservative used for storage of blood/red cells in liquid form.
GIBSON (1957)
The use of “Phosphate” is what made CPD less acidic than ACD.
GIBSON (1957)
Shelf-life of blood stored in CPD
2 - 4 ºC was 21 days
CPDA-1 extends the shelf life of whole blood from 28- 35 days, increasing the blood supply and facilitating resource sharing among blood banks.
1979
The addition of adenine improved the synthesis of ATP in the stored blood, which prolonged the storage of blood/red cells
2 - 4 ºC to 35 days
refers to the 120 days span of RBCs within the body
Lifespan
refers to the lifespan of RBCs during the storage period.
Shelf life