LMR Flashcards
Osteoporosis risks
-caffeine, smoking
-lack of weight bearing exercises
-lack diet rich in Ca and Vit D
What is increased in rheumatoid arthritis?
Erythrocyte Sedimentation Rate
What labs should you check with/ macrocytic normochromic anemia?
Vitamin B12 and Folic Acid
(Note: this is a severe form of anemia, RBCs larger than should be
What is increased in autoimmune disorders?
Cytokines
(Proteins that effect the immune system)
Disseminated encephalomyelitis S/S?
Weakness, paresthesia, *asymmetrical body movement (extremities)
- do neuro exam, this is a neuro d/o w/ inflammation in brain and spinal cord- damages myelin
Clozapine is metabolized by____?
CYP1A2* and CYP2B6
Limbo system includes:
Amygdala, Hippocampus, thalamus, hypothalamus, basal ganglia, anterior cingulate gyrus
Where is Ach synthesized?
Basal nucleus of Meynert
Meds that cause Depression
Steroids, beta blockers, interferons, isotrenitoin (Accutane), some retroviral drugs, antineoplastic drugs, benzos, progesterone
Lithium S/E
Hypothyroidism, fine hand tremors, GI upset (cramps, V/D, anorexia) diabetes insipidus, polydipsia, polyuria, t-wave inversion, maculopapular rash, Leukocytosis
Lithium toxicity
Severe N/V/D, coarse hand tremors, muscle weakness, ataxia, heart palpitations
Drugs that reduce renal clearance
NSAIDS, thiazides, ACE inhibitors
-increases concentration of drugs cleared by kidney like lithium
Lithium can be increased due to ___ and _____
Hyponatremia and dehydration
Signs of hepatotoxicity
RUQ pain, reddish brown urine, yellowing of skin/whites of eyes, fatigue
-if taking depakote: DC depakote and check LFT
Signs of depakote toxicity
N/V, lethargy, disorientation, respiratory depression
-DC depakote, check serum dep levels, LFTs and ammonia
S/S pancreatitis
Fever, tachy, N/V/ oily stools
Upper abd pain, abd pain radiating to back, tender abd w/out touch
Aplastic anemia s/s
(Stop producing new blood cells)
Pallor, fatigue, SOB, HA, fever, skin rash, bleeding gums, nose bleed
S/S infection
Sore throat, sudden fever, chills, weakness
Alpha delta 2 ligands
Gabalin and pregabalin - can use for chronic pain w/out depression
Labs NMS
Increased CPK, LFTs, WBCs (leukocytosis) and myoglobinuria
Tx NMS
DC offending agent first
Bromocriptine (Parlodel) =D2 agonist
Dantrolene (Dantrium) = muscle relaxant
3 meds that delay gastric emptying
Omeprazole, famotidine, ranitidine
Negative symptoms of schizophrenia
Affective flattening, avolition, alogia, anhedonia, apathy, attention deficits, abstract thinking probs
DMDD med for severe irritability
Ritalin
Signs of stimulant abuse
Insomnia, tremor, heart palpitations, Anxiety, Agitation, irritable, mood swings, increased HR and BP,
What med for delirium agitation /psychosis
Low dose Haldol