Liver

Question 1

What zone of the liver is the most sensitive to heptotoxins?

Answer 1

Zone 1

Question 2

Which zone of the liver is most prone to hypoxia?

Answer 2

Zone 3

Question 3

What on U/s indicates pathology of the liver?

Answer 3

rounded edges; However, normal apperance does NOT mean no liver disease

Question 4

what is the best biospy techinque for the liver?

Answer 4

surgical wedge

Question 5

How can you tell if an increase in AST is due to muscle?

Answer 5

CK will rise too

Question 6

ALP isoenzymes

Answer 6

Can be cortisol induced

Question 7

Which is more indicative of cholestasis, ALP or GGT?

Answer 7

GGT

Question 8

When will you clinically see bile elevations as iceterus? When will you see it in serum?

Answer 8

2-3= clinical

1-2= seen in serum

Question 9

What are the synethic factors?

Answer 9

BUN, albumin, cholesterol, glucose

Question 10

Do we need to run bile acids in an icteric patient?

Answer 10

No!!!

Question 11

Hepatopathy

Answer 11

an abnormal or diseased state of teh liver

Question 12

hepatitis

Answer 12

inflammation affecting the hepatocytes

Question 13

cholangitis

Answer 13

inflammation of the bile ducts

Question 14

cirrhosis

Answer 14

scarring of the liver

Question 15

What are some endocrinopathies that affect the liver?

Answer 15

Hyperthyroid

Cushings

Question 16

Canine Breed Associated Hepatopathies

Answer 16

Immune mediated/inflammatory- cockers, dobs, poodle

Copper storage disease- Bedlington, labs

Question 17

amyloid deposition breeds

Answer 17

shar peis,abyssinian, simase

Question 18

What are the CS of copper storage disease?

Answer 18

glucosuria

elevated ALT

Question 19

What’s the main medication for copper chelation?

Answer 19

D-penicillamine

Question 20

What is the most common acquired inflammatory liver disease in cats?

Answer 20

Cholangitis/ cholangiohepatitis syndrome

Question 21

What’s the treatment for a galbladder mucocele?

Answer 21

SURGERY

abdominal u/s is used to confirm dx

Question 22

What is the cause of hepatic lipidosis?

Answer 22

IT’s secondary to another disease process- disease= whatever made them stop eating

Question 23

How does hepatic lipidosis occur?

Answer 23

typically overweight cats preceded by some period of anorexia

Question 24

What will you see on chemistry for hepatic lipodosis?

Answer 24

ALP increases greater than hepatocellular enzyme increases

Question 25

What are CS of a congenital PSS?

Answer 25

star gazing, head pressing after meals, PU/PD from decreased urea production

Question 26

What’s the therapy for congenital PSS?

Answer 26

Metro

Lactulose

Low protein diet