Lipids Flashcards
In familial hypercholesterolemia, the hallmark finding is an elevation of one of the following”
LDL
If the LDL-cholesterol is to be calculated by the Friedewald formula, what two measurements must be carried out using the same chemical procedure.
Total cholesterol and HDL cholesterol
A molecule common to both the citric acid cycle and lipid metabolism is____.
Acetyl CoA
What will be the concentration of HDL cholesterol given the following data:
OD of unknown= 0.175
OD of standard= 0.22
Concentration of standard= 1,17 mmol/L
0.93
The function of the major lipid components of the VLDL is to transport:
Endogenous triglycerides
High levels of which lipoprotein class are associated with decreased risk of accelerated atherosclerosis?
HDL
The lipoprotein that travels with B globulins during electrophoresis is ____.
LDL
______ are proteins that combine with lipids and aid in their transport.
Lipoproteins
The type of lipoprotein with a high atherogenic potential is ______.
LDL
As part of the hyperlipidemia screening program, the results below were obtained from a 25 year old 6 hours after eating. Which of the choices below is the BEST interpretation of these results? Triglycerides= 2,93 mmol/L Cholesterol= 3,10 mmol/L
The cholesterol may be normal but
the triglycerides are elevated which
may be attributed to the recent meal
Turbidity in serum suggests elevation of:
Chylomicrons
The parent substance in the biosynthesis of androgen and estrogens is:
Cholesterol
____ is used to precipitate proteins in the Bloor’s method for cholesterol determination.
CHCI3
The lipoprotein that transports endogenous triglycerides is _______.
VLDL
An increase in fats and fatty acids in the blood is called _____.
Hyperlipidemia
The most widely used support medium for electrophoretic separation of lipoprotein is:
Agarose gel
The precipitant of choice in the non enzymatic method for cholesterol determination is ______.
Digitonin
Which of the following lipid results would be expected to be falsely elevated on a serum specimen from a non-fasting patient?
Triglycerides
_____ seconds is the peak absorbance in Ferro-Ham method for cholesterol determination.
60
The organ that plays an important role in cholesterol metabolism is ____
Liver
______ is the breakdown or hydrolysis of a substance such as triglycerides into fatty acids.
Saponification
A fasting serum sample from an asymptomatic 43-year old woman was examined visually and chemically with the results shown below. What lipoprotein fractions would predominate? Initial appearance of serum is milky. After an overnight refrigeration a cream layer over a turbid serum was found
Triglyceride level= 22,58 mmol/L Cholesterol level= 14,22 mmol/L
Chylomicrons
VLDL
What will be the cholesterol value for the data below:
OD of unknown= 0.455
OD of standard= 0.32
Concentration of standard= 5,27 mmol/L
7.35
Which of the following diseases results from a familial absence of HDL?
Tangier
not considered as a polyanion precipitant:
Digitonon
What transports 60-77% of the plasma cholesterol?
LDL
The most metabolically active plasma lipids is ______.
FFA
Most of the cholesterol esters found in the blood are cholesterol combined with
LDL
The most consistent analytical error involved in the routine determination of HDL-cholesterol is caused by:
Co-precipitate of HDL and LDL-cholesterol
Premature atherosclerosis can occur when which of the following becomes elevated?
LDL
In the colorimetric and fluorometric triglyceride assays, glycerol is oxidized to _______.
Formaldehyde
The lipoprotein that possesses Apo B 48 is _______.
Chylomicrons
In lipoprotein phenotyping, chylomicrons are present in the plasma of persons with which of the following lipoprotein phenotypes?
I and IV
What will be the triglyceride concentration given the data below:
OD of unknown= 0.30
OD of standard= 0.265
Concentration of standard= 2,59mmol/L
2,93
Most of the fatty acids are bound by ____ in the plasma.
Albumin
Apolipoprotein B (Apo-B-100) is the major apolipoprotein found in:
LDL
Using the value you have obtained to compute Total cholesterol, triglycerides and HDL-cholesterol, what will be the LDL cholesterol?
5,09 mmol/L
Triglycerides in circulation are cleared by the enzyme
Lipoprotein lipase
____ lipoprotein transport cholesterol to other tissues for membrane and steroid synthesis.
LDL
Bile acids are synthesized from _____.
Cholesterol
