LESSON 1.2: CHROMOSOME COMPONENTS AND STRUCTURE DISCOVERY

Question 1

In 1944, ______ and not ____ in chromosomes is the heredity material ( through genetic transformation experiment.)

Answer 1

DNA and not protein

Question 2

In 1950 & 1953, he ff discovered the amount of nitrogen base in chromosome.

Answer 2

Chargaff

Question 3

In 1950, 1953, they discovered the double helix.

Answer 3

Watson and Crick

Question 4

In _______, there was a Discovery of the genetic code in protein synthesis.

Answer 4

1961

Question 5

The first report of CGH analysis was by _________ in _______ at the University of California, San Francisco, who utilized CGH in the analysis of solid tumors

Answer 5

Kallioniemi and colleagues in 1992

Question 6

The implementation of_______, whereby DNA microarrays are used instead of the traditional metaphase chromosome preparation, was pioneered by Solinas-Tolodo et al. in 1997 using ________ and Pinkel et al. in 1998 by use of___________

Answer 6

array CGH; tumor cells; breast cancer cells

Question 7

What year does HPG launched in the US and a First gene for breast cancer (BRAC1) was mapped?

Answer 7

1990

Question 8

New 5-year plan for the HGP in the US published. The Sanger Centre founded near Cambridge, UK.

Answer 8

1993

Question 9

Full scale human genome sequencing begins. A sequence of first human chromosome (22) completed

Answer 9

1999

Question 10

Draft version of human genome.
Fruitfly genome sequenced.
Mustard cress genome sequenced.

Answer 10

2000

Question 11

Finished version of human genome sequence completed.

Answer 11

2003