Lecture 61 - Penicillins Flashcards

1
Q

Penicillins are bacterio____. They bind PBP, inhibiting the transpeptidase reaction.

A

Bacteriocidal

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2
Q

Beta-lactams can be coupled with Beta-lactamase inhibitors (BLIs).

Amoxicillin + ______
Ticarcillin + ______
Ampicillin + ______
Piperacillin + ______

Just keep in mind some beta-lactamases cannot be inhibited by the BLIs.

A

Amoxicillin + Calvulinic acid

Ticarcillin + Calvulinic acid

Ampicillin + Sulbactam

Piperacillin + Tazobactam

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3
Q

Penicillin interacts with oral _______, and can decrease their effectiveness. Also, ______ is a drug used to treat gout and competes with Penicillin for renal secretion –> higher serum penecillin bc not excreted.

A

Contraceptives

Probenacid

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4
Q

Monobactams are ONLY effective against Gram ____ bacilli.

A

Gram -

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5
Q

Imipenem, Doripenem, Meropenem, and Ertapenem are all _______. Which of the four is the only one inactivated by renal dehydropeptidases and what is given as an inhibitor of this renal enzyme?

A

Imipenem is inhibited by renal dehydropeptidase, and Cilastatin is given as an inhibitor of this enzyme.

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