Lecture 61 - Penicillins Flashcards
Penicillins are bacterio____. They bind PBP, inhibiting the transpeptidase reaction.
Bacteriocidal
Beta-lactams can be coupled with Beta-lactamase inhibitors (BLIs).
Amoxicillin + ______
Ticarcillin + ______
Ampicillin + ______
Piperacillin + ______
Just keep in mind some beta-lactamases cannot be inhibited by the BLIs.
Amoxicillin + Calvulinic acid
Ticarcillin + Calvulinic acid
Ampicillin + Sulbactam
Piperacillin + Tazobactam
Penicillin interacts with oral _______, and can decrease their effectiveness. Also, ______ is a drug used to treat gout and competes with Penicillin for renal secretion –> higher serum penecillin bc not excreted.
Contraceptives
Probenacid
Monobactams are ONLY effective against Gram ____ bacilli.
Gram -
Imipenem, Doripenem, Meropenem, and Ertapenem are all _______. Which of the four is the only one inactivated by renal dehydropeptidases and what is given as an inhibitor of this renal enzyme?
Imipenem is inhibited by renal dehydropeptidase, and Cilastatin is given as an inhibitor of this enzyme.