Lecture 6 Review Questions

Question 1

What happens during the 6 steps outlined in the model for regulating AMPA receptors?

Answer 1

1. Ca2+ flows into NMDA receptor
2. CamKII is activated
3. CamKII is sent to synapse and to RAS-ERK signaling area
4. Exocytosis of AMPA receptor via PKA and S845 (stargazin is also attached)
5. PKC and S818 and Stargazin on AMPA is phosphorylated, allowing stargazin to bind to PSD95
6. Phosphorylation of GLU by CamKII and S831 increase the channel conductance of AMPAs