Lecture 6 Pharmacokinetics Flashcards
1
Q
what is pharmacodynamics
A
mechanism of action of the drug and effects on cellular functions
2
Q
what does the physiochemical properties affect
A
affinity, efficacy and potency
3
Q
in pharmacokinetics what does the drug have an affect on?
A
absorption, distribution, metabolism and excretion
4
Q
mechanism of bulk flow
A
- used to distribute drugs in the blood to bring the drug to its target but also used for elimination.
- can be affected by distribution of drug is tissue but also the access of the target.
5
Q
mechanism of diffusion
A
- aqueous diffusion carries drugs to and from hydrophobic barriers.
- smaller the drug the quicker the diffusion.
pinocytosis important for transferring macromolecules across the BBB.
6
Q
mechanism of carriers
A
- solute carriers involved in transport of large molecules which may influence drug distribution.
7
Q
factors affecting absorption - diffusion through lipids
(physiochemical properties of the drug)
A
- diffusion across lipids depends on concentration gradient and diffusion coefficient.
- concentration gradient depends on lipid-water partition coefficient.
8
Q
what is lipid solubility (partition coefficient)
A
how readily molecule dissolves into water vs oil
9
Q
the diffusion coefficient
A
inversely related to molecular weight of molecule
