Lecture 6- Connective Tissue

Question 1

Components of extracellular matrix

Answer 1

Intercellular fibers (tensile strength and elasticity)

Amorphous ground substance (compressive strength)

Question 2

Intercellular fibers

Answer 2

Collagen, reticular, and elastic fibers

Produced by fibroblasts

Question 3

Procollagen

Answer 3

What is released by cells and is cleaved into collagen in extracellular space

Question 4

Arrangement of collagen fibers

Answer 4

Spontaneously become parallel and cross link using lysyl oxidase

Question 5

Reticular fibers

Answer 5

Composed of type III collagen

Question 6

Elastic fibers

Answer 6

Composed of elastin and fibrillin

Question 7

Marfan’s syndrome

Answer 7

Mutation in gene that produces fibrillin

Integrity of elastin fibers is lost

Question 8

Ground substance

Answer 8

Provides compressive strength

Composed of proteoglycans and glycosaminoglycans

Question 9

GAGs in ground substance

Answer 9

Chondroitin sulfate, keratan sulfate, and hyaluronic acid

Question 10

Proteoglycans

Answer 10

Protein core with bound GAGs

Can form proteoglycan aggregates where lots of proteoglycans form around hyaluronic acid

Question 11

Basal lamina

Answer 11

Interface between connective tissue and overlying epithelium