Lecture 3 HIV and AIDS Flashcards
1
Q
How does HIV affect the immune system
A
HIV infects and destroys cells of the immune system especially the T-Helper cells that are CD4+
2
Q
What CD4 count do most AIDS diagnoses occur
A
<200
3
Q
What is Stage 1 of HIV
A
Asymptomatic (5-8 years)
4
Q
What is Stage 2 of HIV
A
Weight loss, oral thrush, superficial fungal skin infections
5
Q
What is Stage 3 of HIV
A
Lose significant weight loss, more extensive oral thrush
6
Q
What is Stage 4 of HIV
A
end stage (Pneumonia, Cryptococcal meningitidis, Cytomegalovirus)
7
Q
Name defining conditions of AIDS
A
- TB
- Pneumocystis
- Cerebral toxoplasmosis
- Primary cerebral lymphoma
- Cryptococcal meningitis
- Progressive multifocal leukoencephalopathy
- Kaposi’s sarcoma
- Persistent cryptosporidiosis
- Non-Hodgkin’s lymphoma
- Cervical cancer
- Cytomegalovirus retinitis
8
Q
When does primary HIV symptoms develop
A
2-3 weeks after HIV exposure
9
Q
What are the symptoms of primary HIV
A
o Flu-like illness o Fever o Malaise and lethargy o Pharyngitis o Lymphadenopathy o Toxic exanthema
10
Q
Name the 3 modes of action of ART
A
Reverse transcription inhibitors
Integrase inhibitors
Protease inhibitors
