Lecture 3

Question 1

MHC 1 are expressed by what kind of cells and from what sources

Answer 1

Nucleated Cells and Endogenous Sources

Question 2

MHC II are expressed by what cells and are derivived from what source

Answer 2

APC and exogenous sources

Question 3

CD8+ T Cells are

Answer 3

Cytotoxic Cells (Tc)

Question 4

CD4+ T Cells are

Answer 4

Helpher Cells (Th)

Question 5

This T cell has CYTOTOXIC functions to eliminate infected or damaged cells and cancer cells

Answer 5

CD8+ T Cells

Question 6

This T cell produces CYTOKINES to direct activities of other immune cells and tissue cells

Answer 6

CD4+ T Cells

Question 7

What allows cross presentation of antigens and activation of CTL

Answer 7

Dendritic Cells
special ability to capture exogenous antigen and redirect it to the MHC class 1 pathway
can take exogenous antigens and activate CD8

Question 8

TH2 cells target what microbes

Answer 8

HELMINTH parasites

eosinophils, mast cells, basophills

Question 9

TH17 cells Target what microbes

Answer 9

EXTRACELLULAR BACTERIA

neutrophills

Question 10

What cells help B-Cell activation

Answer 10

T Follicular Helper Cells

Question 11

Which immunoglobulin is MC found in mucousal tissues

Answer 11

IgA

Question 12

Where does robust B cell proliferation occur

Answer 12

in the DARK ZONE of the germinal center

Question 13

what is it called when the antigen binding site is mutated to improve binding

Answer 13

Somatic Hypermutation

Question 14

Apart of B Cell Activation process

What happens in the Light Zone of the Germinal Center

Answer 14

B cells compete –> high affinty B cells undergo affinty maturation (attached to follicular DC)
Low affinty B Cells undergo apopotosis
The survival B cells –> plasma cells – IgM

Question 15

The intial antibody that is produced before class switching occurs with the help of cytokines

Answer 15

IgM

Question 16

What cytokine produces IgG

Answer 16

IFN-gamma

Question 17

What cyokine produces IgA

Answer 17

TGF-Beta

Question 18

Cytokine IL-4 produces what antobody

Answer 18

IgE and IgG4

Question 19

Cytokines IL-2, IL-4 and IL-5 produce what antibody

Answer 19

IgM

Question 20

Antibody-dependent cell cytotoxicity (ADCC)

What antibody releases perforin and granzyme to induce apoptosis of the target cell

Answer 20

IgG

Question 21

Osponization

what antibody can trigger phagocytosis

Answer 21

IgG

Phagocytes express Fc receptors that bind to the Fc portion of IgG

Question 22

What antibody is involved in antibody mediated activation of complement

Answer 22

IgM and IgG
C1 binding triggeres membrane attack complex (MAC) –> lysis

Question 23

What allows fluid movement resulting in cell lysis

Answer 23

MAC (membrane attack complex) which is triggered from the C1 binding after IgM binded to the surface of the microbe

Question 24

What antibodies are invovled in neutralization

Answer 24

IgG and IgA – prevent microbe ligand interaction with host cell preventing invasion
Method is also used by anti-toxins

Question 25

What antibody is involved in the ADCC of parasotes

(Helminth = parasitic worm)

Answer 25

IgE – binding triggers release of granule contents that destroy the microbes

Question 26

What anitbody is involved in allergic responses

Answer 26

IgE – triggers granule release by mast cells – producing rapid inflammatory response