Lecture 2

Question 1

There are 5 ways that substance can move across capillary membrane into the brain mention them

Answer 1

• passive diffusion
• facilitated diffusion
• active transport
  -vesicular transfer
• aqueous transfer

Question 2

What is CSF ?

Answer 2

Extracellular fluid filtered from the blood

Question 3

What is the normal amount if CSF

Answer 3

140ml to 150 ml

Question 4

What is the rate of production of CSF in one day ?

Answer 4

550 ml

Question 5

Where can we find CSF

Answer 5

ventricles , spinal cord central canal and sub-arachnoid space ( majority )

Question 6

CSF is reabsorbed by what and where to and why reabsord it ?

Answer 6

Arachnoid villi into venous sinuses to reduce the pressure

Question 7

CSF IS PRODUCED BY TWO WAYS MENTION THEM ?

Answer 7

-choroid plexus through Ependyma
- directly by blood vessels through astrocyte
-

Question 8

The per cent of CSF produced by choroid plexus ?

Answer 8

50% - 70%

Question 9

What are the functions of CSF

Answer 9

Buoyancy
Protective function

Question 10

What is the normal pressure of CSF ? What will happen If it’s high or low

Answer 10

120 - 180 ( 9-14 mmHg)
Low dehydration
High tumour

Question 11

What is the amount of red blood cell in CSF

Answer 11

None

Question 12

What will happen If white blood cell increased in the CSF

Answer 12

Meningitis and parasitic infections

Question 13

What will happen if the glucose in the CSF is high or low ?

Answer 13

Low : meningitis
High : diabetes

Question 14

The composition of CSF is regulated by what ?

Answer 14

BBB

Question 15

In terms of substance movement across capillary into the brain the passive diffusion is directly proportional to (a)……….. and inversely proportional to (b) …………

Answer 15

(a) lipid solubility
(b) size