lecture 17 Flashcards
what signals are needed for T cells to become fully activated
signals 1 and 2
can a T cell become activated with 1 signal
no
how does signal 1 work
antigen communicating through the T cell receptor but it doesnt provide full activation of T cell
how does signal 2 work
only occurs if antigen present is in context of danger scenario and works through direct molecular communication of APC
what does adhesion molecules do
stabilize the positioning of the APC beside the T cell by holding them together
what does signal 1 work through
antigen presentation
what does signal 2 work through
co stimulator
what are co stimulatory molecules
B7 family of CD80 and CD86 on APC and work through TCR CD28
what are phagocytosed if there are no infectious cells
non pathogenic proteins
what happens if there is no danger scenario
the T cell is driven toward anergy as it cannot be fully activated
what is the function of signal 3
to further drive activation of the T cell
what is signal 3
cytokine signal released by the APC of helper cells which make its way to the cytokine receptor on the T cell
how many different cytokines in human
200
do cytokines activate NK cells
yes
what is one of the functions of cytokines for CD8 T cells
regulate proliferation
