lecture 13

Question 1

what are the top three most prescribed opioids in order

Answer 1

hydrocodone, oxycodone and methadone

Question 2

opioids good for what kind of pain?

Answer 2

acute but not chronic

Question 3

name some of the actions of morphine

Answer 3

constipation, suppression of cough reflex, constriction of pupil, increase parasympathetic, analgesia, sedation, respiratory depression, nausea, pruritus, convulsions

Question 4

little tolerance built towards what symptoms of morphie?

Answer 4

constipation and miosis

Question 5

recovery from morphone withdrawal after how many days?

Answer 5

5

Question 6

what happens with morphine withdrawal as far as parasympathetic/sympathetic? what meds are given?

Answer 6

increase sympathetic, pupil dilation. clonidine is given to decrease sympathetic (alpha 2 agonist)

Question 7

overdose toxicity more common with what drug and why?

Answer 7

methadone because of longer half life

Question 8

most common cause of opioid death is due to what

Answer 8

hypoxic end organ injury due to respiratory depression

Question 9

three receptors for opioids

Answer 9

mu, delta, and kappa

Question 10

which receptor has the analgesic and addictive properties?

Answer 10

mu

Question 11

buprenorphine is what?

Answer 11

partial agonsit