Lecture 1: Basic Review

Question 1

What are the functions of the immune system?

Answer 1

Defines self/ Identifies non-self

Protects against spontaneously developing cancer cells

Protects against bacteria/viral/fungal infection

Signals distress via cytokine/hormones Cross-talks with the nervous and endocrine system

Question 2

What are the major organs in both secondary and primary systems?

Answer 2

Primary- thymus, bone marrow

Sec - lymph nodes, tonsils, and adenoids, spleen, and bone marrow, peyers patch

Question 3

Overview of Immune Systems; acquired and innate

Answer 3

look at slide 3

Question 4

What are the barriers that protect us from invasion?

Answer 4

Non-specific Physical & Chemical Defense
- skin, mucous, lysozymes in tears, stomach acid, coughing etc,

Innate
- macrophages, neutrophils, basophils, monocytes, eosinophils

Adaptive Immunity
cellular and humoral

Question 5

Mechanism of Marcophage

Answer 5

1) antigen is in intracellular vesicles
2)endosomes of neutral pH endosomal proteases are not active
3) acidification promotes proteases to degrade antigens
4) vesicles with peptides mix with vesicles that have MHC class 2 molecules

Question 6

What happens in the Thymus?

Answer 6

• t-lymph develop, mature, and differentiate in the thymus