Lec 14/15 Flashcards
erythropoietin is a?
166 amino acid glycoprotein
define Recombinant DNA
modified DNA strand that is produced when a small piece of DNA is added to the genome (DNA molecule) of another organism
t/f biotechnology encompasses any technique that uses living organisms in the production or modification of products.
true
T/F oral administration can be used for most protein drugs
false, not for most protein drugs
define basal insulin
insulin normally supplied to pancreas with or w/o food
define bolus insulin
insulin produced in response to glucose
basal insulins are intermediate/long acting or rapid/short acting?
intermediate/long acting
bolus insulins are intermediate/long acting or rapid/short acting?
rapid/short acting
lispro, aspart, and glulisine are which type of insulin?
rapid-acting
regular humulin or novolin are which type of insulin?
short-acting
isophane is which type of insulin?
intermediate-acting
glargine and detemir are which type of insulin?
long-acting
short-acting (Humulin R) insulin may be stored at room temperature for how many days?
can it be frozen?
28 days
no
t/f rapid-acting insulin should be given right before or right after a meal
true
what is Lipohypertrophy?
a lump under skin caused by accumulation of extra fat that typically occurs due to SC injections of insulin
growth hormone deficiency occurs due to?
pituitary gland not producing enough growth hormone
what is the name of the drug used as growth hormone replacement therapy?
somatropin
Lepirudin (refludan) is what drug class?
anticoagulant drugs
tissue plasminogen activator is a protein involved in the breakdown of?
what is it used for?
blood clots
acute myocardial infarction, stroke, and pulmonary embolism
alteplase (activase) is what drug class?
tissue plasminogen activator
what is hemophilia?
a bleeding disorder
antihemophilic factor (kogenate, recombinate) is what drug class?
clotting factor
Colony Stimulating Factors (CSF) are glycoproteins that stimulate stem cells in
bone marrow to form a specific kind of white blood cell called?
neutrophil
filgrastim (neupogen, imumax, grafeel) is what drug class?
what is it used for?
Colony-Stimulating Factor
cancer treatment
Erythropoietin (EPO) is a glycoprotein hormone that stimulates the production of _________ by stem cells in bone marrow
EPO is mainly produced by?
red blood cells
the kidneys
epoetin alfa (epogen, procrit) is what drug class? what is it used for?
Erythropoietin
anemia
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are the same because they are made by?
identical immune cells that are clones of a unique parent cell
what is hybridoma technology?
produces identical antibodies in almost unlimited quantities
rituximab (rituxan) drug class?
use?
MAb
treat cancers of WBCs such as leukemias and lymphomas
Trastuzumab (Herceptin) drug class?
use?
MAb
block growth of tumors by binding to HER2 receptors
Bevacizumab (Avastin) drug class?
use?
MAb
stop new blood vessels from forming to treat certain cancers
Ibritumomab Tiuxetan (Zevalin) drug class? use?
MAb
delivers radiation drug to cancer cells to treat B cell non-Hodgkin’s lymphoma
Ado-trastuzumab Emtansine (Kadcyla) drug class?
use?
deliver chemo drug to cancer cells to target HER2 protein to treat breast cancer
Satumomab Pendetide (OncoScint) drug class? use?
MAb
used to diagnose cancer
Muromonab-CD 3 (Orthoclone OKT3) drug class?
use?
MAb
prevent organ rejection
Adalimumab (Humira) drug class?
use?
what cytokine does it block?
MAb
treat rheumatoid arthritis
TNF
what is measured in the urine by pregnancy tests?
hCG
Fomivirsen Sodium (Vitravene) drug class? use?
MAb
treats retinitis by blocking translation of CMV gene
