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Pharmaceutics I > Lec 14/15 > Flashcards

Lec 14/15 Flashcards

1
Q

erythropoietin is a?

A

166 amino acid glycoprotein

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2
Q

define Recombinant DNA

A

modified DNA strand that is produced when a small piece of DNA is added to the genome (DNA molecule) of another organism

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3
Q

t/f biotechnology encompasses any technique that uses living organisms in the production or modification of products.

A

true

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4
Q

T/F oral administration can be used for most protein drugs

A

false, not for most protein drugs

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5
Q

define basal insulin

A

insulin normally supplied to pancreas with or w/o food

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6
Q

define bolus insulin

A

insulin produced in response to glucose

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7
Q

basal insulins are intermediate/long acting or rapid/short acting?

A

intermediate/long acting

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8
Q

bolus insulins are intermediate/long acting or rapid/short acting?

A

rapid/short acting

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9
Q

lispro, aspart, and glulisine are which type of insulin?

A

rapid-acting

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10
Q

regular humulin or novolin are which type of insulin?

A

short-acting

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11
Q

isophane is which type of insulin?

A

intermediate-acting

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12
Q

glargine and detemir are which type of insulin?

A

long-acting

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13
Q

short-acting (Humulin R) insulin may be stored at room temperature for how many days?
can it be frozen?

A

28 days

no

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14
Q

t/f rapid-acting insulin should be given right before or right after a meal

A

true

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15
Q

what is Lipohypertrophy?

A

a lump under skin caused by accumulation of extra fat that typically occurs due to SC injections of insulin

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16
Q

growth hormone deficiency occurs due to?

A

pituitary gland not producing enough growth hormone

17
Q

what is the name of the drug used as growth hormone replacement therapy?

A

somatropin

18
Q

Lepirudin (refludan) is what drug class?

A

anticoagulant drugs

19
Q

tissue plasminogen activator is a protein involved in the breakdown of?
what is it used for?

A

blood clots

acute myocardial infarction, stroke, and pulmonary embolism

20
Q

alteplase (activase) is what drug class?

A

tissue plasminogen activator

21
Q

what is hemophilia?

A

a bleeding disorder

22
Q

antihemophilic factor (kogenate, recombinate) is what drug class?

A

clotting factor

23
Q

Colony Stimulating Factors (CSF) are glycoproteins that stimulate stem cells in
bone marrow to form a specific kind of white blood cell called?

A

neutrophil

24
Q

filgrastim (neupogen, imumax, grafeel) is what drug class?

what is it used for?

A

Colony-Stimulating Factor

cancer treatment

25
Q

Erythropoietin (EPO) is a glycoprotein hormone that stimulates the production of _________ by stem cells in bone marrow
EPO is mainly produced by?

A

red blood cells

the kidneys

26
Q 
epoetin alfa (epogen, procrit) is what drug class?
what is it used for?
A

Erythropoietin

anemia

27
Q

Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are the same because they are made by?

A

identical immune cells that are clones of a unique parent cell

28
Q

what is hybridoma technology?

A

produces identical antibodies in almost unlimited quantities

29
Q

rituximab (rituxan) drug class?

use?

A

MAb

treat cancers of WBCs such as leukemias and lymphomas

30
Q

Trastuzumab (Herceptin) drug class?

use?

A

MAb

block growth of tumors by binding to HER2 receptors

31
Q

Bevacizumab (Avastin) drug class?

use?

A

MAb

stop new blood vessels from forming to treat certain cancers

32
Q 
Ibritumomab Tiuxetan (Zevalin) drug class?
use?
A

MAb

delivers radiation drug to cancer cells to treat B cell non-Hodgkin’s lymphoma

33
Q

Ado-trastuzumab Emtansine (Kadcyla) drug class?

use?

A

deliver chemo drug to cancer cells to target HER2 protein to treat breast cancer

34
Q 
Satumomab Pendetide (OncoScint) drug class?
use?
A

MAb

used to diagnose cancer

35
Q

Muromonab-CD 3 (Orthoclone OKT3) drug class?

use?

A

MAb

prevent organ rejection

36
Q

Adalimumab (Humira) drug class?
use?
what cytokine does it block?

A

MAb
treat rheumatoid arthritis
TNF

37
Q

what is measured in the urine by pregnancy tests?

A

hCG

38
Q 
Fomivirsen Sodium (Vitravene)
drug class?
use?
A

MAb

treats retinitis by blocking translation of CMV gene

Pharmaceutics I (6 decks)

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