Lactate Flashcards
Acid
Compound that donates H+
Base
Compound that gives up OH
Resting muscle and Blood pH
Muscle- 6.9-7.1
Blood- 7.4 (to regulate cellular acidity)
Formula for lactate
C3H5O3
- does not diffuse into blood for buffering
Cannot give up H+
Does Lactate cause muscle acidosis?
NO
- Actually does the opposite as it consumes an H+
NADH H+ ↓ NAD+
Lactate Shuttle
MCT1 shuttle
- Lactate can be transported between muscles or organs to be used as fuel)
Where does lactate go?
1) TO muscles, tissues
2) Excreted through sweat and urination
3) TO liver to be converted into glucose
Blood lactate levels correlate to?
H+ levels
Acidification of blood and muscles
Blood lactate threshold
The point of %VO2 (exercise intensity) that lactate increases rapidly
50% in untrained
75% in trained
Where does H+ come from in anaerobic exercise
1) Intermediary steps of glycolysis
2) Hydrolysis of ATP
How does high intensity exercise affect pH
An increase in H+ and decrease in pH
Muscle- lowest recorded was 6.4
Blood- around 7
A decrease in pH relates to
A decrease in muscular force production
Buffering capacity
Ability to resist change in muscle pH
Highest in sprinters
Lower in marathon runners (do not reach lactate threshold)