L8

Question 1

Dosage of low potency drugs and implications

Answer 1

Low potency = higher dose needed to produce effect

- higher chance to activate some other sites and give side effects

Question 2

Receptor definition

Answer 2

A protein whose function is to recognise and respond ti endogenous chemicals, or ‘sense’ the environment
Have a ligand-bindding site which only recognises specific ligands

Question 3

Drug targets apart from receptors

Answer 3

other molecules which also interact with drugs

Question 4

Classification of receptors

Answer 4

by their structure, pharmacology and signalling

Question 5

Direct/ Indirect signalling

Answer 5

Direct signalling doesn’t involve any protein other than the receptor

Indirect signalling needs proteins which will transduce the signal

Question 6

Inverse agonist

Answer 6

Binds to the receptor and stabilises it, preventing it from stopping propagating the signal

Question 7

Antagonist

Answer 7

Binds to a receptors and prevents it from signalling by blocking the ligand-binding site

Question 8

Drug targets

Answer 8

Ion channels, Enzymes, Transporters, microtubules