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BMS242 Cell & Molecular > L14 Vesicular Trafficking I > Flashcards

L14 Vesicular Trafficking I Flashcards

1
Q

What types of SNAREs are there

A

v-SNAREs and t-SNAREs

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2
Q

What are transport vesicles coated in?

A

Clathrin, COPI & COPII

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3
Q

What is a paradigm for transport vesicle formation

A

COPII coated vesicle

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4
Q

What associates with the rough ER

A

ribosomes

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5
Q

How are newly made proteins translocated into organelles

A

co-translationally or post-translationally

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6
Q

What does translocation into the ER require

A

signal

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7
Q

How are membrane proteins inserted into the ER

A

signal peptidase

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8
Q

What ensures proper protein folding in the ER

A

chaperones

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9
Q

What do defects in protein folding give rise to

A

disease

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10
Q

What do misfolded proteins stimulate?

A

unfolded protein response

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11
Q

What are the essential components for all transport vesicle formation

A

GTPase, adaptor proteins, and coat

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12
Q

What act as molecular switches

A

GTPases

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13
Q

What converts GDP to GTP

A

guanine nucleotide exchange factors

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14
Q

What converts GTP to GDP

A

GTPase activating proteins

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15
Q

Where is GDP form usually found

A

cytosol

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16
Q

Where is GTP form usually found

A

membrane

17
Q

What is the main member of GTPases

A

Ras

18
Q

What is the GTPase component of COPII

A

Sar1

19
Q

What is the adaptor component of COPII

A

Sec23/24

20
Q

What is the coat component of COPII

A

Sec13/31

21
Q

Adaptor protein function

A

recognise and select cargo ensuring specificity

22
Q

What do adaptor proteins recognise

A

motifs in cytoplasmic domains

23
Q

AP2

A

major clathrin adaptor

24
Q

What is AP2 involved in

A

endocytosis

25
Q

What do coat proteins provide

A

structural scaffold

26
Q

What experiments allow us to understand what makes a COPII vesicle

A

reconstitution experiments

27
Q

Ribophorin

A

resident ER protein

28
Q

P58

A

COPII cargo protein

29
Q

Where are GTPases recruited from

A

cytosol

30
Q

GTP mutant

A

cannot hydrolyse GTP

31
Q

GDP mutant

A

sequester GEFs

32
Q

Mutant GTPases effect

A

dominant negative

33
Q

Expression of Sar1GDP inhibits

A

COPII formation

34
Q

COPII cargo

A

newly synthesised proteins

35
Q

COPI cargo

A

retrieved & newly synthesised protein

36
Q

Clathrin cargo

A

lysosomal proteins, regulated secretory proteins, endocytosed material

BMS242 Cell & Molecular (14 decks)

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