Kawasaki disease Flashcards
1
Q
What is it
A
mucocutaneous lymph node syndrome
acute
childhood
primary vasculitis
of medium arteries (especially coronaries)
2
Q
Complications
A
sometimes aneurysm formation
arterial rupture
MI
death
3
Q
epidemiology
A
uncommon
1-2 year old children
male
Asian (especially Japanese)
4
Q
pathogenesis
A
aberrant immune rxn to RNA virus that can become persistent in genetically prone pts
5
Q
pathology
A
endothelial necrosis
transmural inflammation w/ neutrophils, lymphocytes, necrosis, aneurysms, thrombosis
6
Q
Signs and symptoms
A
persistent high fever
conjunctivitis
mucosal and skin erythema and edema
(esp. palms and soles)
cervical lymphadenopathy
**strawberry tongue
7
Q
Diagnosis
A
Hx and physical examination
8
Q
Treatment
A
aspirin and IV immunoglobulin
prompt treatment can dramatically improve prognosis
