Kallman Syndrome

Question 1

Kallmann’s syndrome is a recognised cause of delayed puberty secondary

Answer 1

hypogonadotropic hypogonadism.

failure of GnRH-secreting neurons to migrate to the hypothalamus.

Question 2

Trait of inheritance of kallman

Answer 2

usually inherited as an X-linked recessive trait - affects males

Question 3

Features of kallman ?

Answer 3

‘delayed puberty - testes un descended decreased pubic hair

hypogonadism,

cryptorchidism

anosmia

patients are typically of normal or above-average height

Cleft lip/palate and visual/hearing defects are also seen in some patients

Question 4

Diagnosis of kallman

Answer 4

GNRH LOW

sex hormone levels are low
LH, FSH levels are inappropriately low/normal