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Question 1

how many times does the receptor cross the membrane?

Answer 1

7 times

Question 2

what are the main effectors?

Answer 2

adenylate cyclase, phospholipase C, ion channels

Question 3

what subunits bind g-proteins to the plasma membrane?

Answer 3

alpha and gamma with covalently attached lipid anchors

Question 4

what is the function of g alpha s?

Answer 4

stimulation of adenylyl cyclase

Question 5

what is the function of g alpha i?

Answer 5

inhibition of adenylyl cyclase, lowering cAMP

Question 6

what is the function of g alpha q/11?

Answer 6

activting PLC, generated IP3 and DAG

Question 7

what is the function of pkA?

Answer 7

catalysing the transfer of phosphate from ATP

Question 8

what kinase can undergo homologous desensitisation?

Answer 8

g protein-coupled receptor kinase (GRK)

Question 9

what kinase can undergo heterologous desensitisation?

Answer 9

protein kinases A and C

Question 10

what happens when a receptor is phosphorylated?

Answer 10

signaling cascade inhibited, promotes receptor internalisation