Introduction to Fungi (Mycology) Flashcards

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1
Q

How many fungi are humans actually susceptible to?

A

200

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2
Q

What are conidia?

A

Conidia are asexual reproductive elements

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3
Q

What are spores?

A

Spores are sexual reproductive elements

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4
Q

What are the two ways that fungi differences are exploited for medical use?

A

Fungi have a rigid cell wall, containing chitin, that can be visualized after treatment with 10% KOH.

Instead of cholesterol, fungi have membranes with ergosterol which is a target for antifungal drugs

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5
Q

Are yeasts multicellular or single cells?

A

Yeasts are single cells

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6
Q

Are molds multicellular or single cells?

A

Molds are multicellular

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7
Q

What are hyphae?

A

Tube-like extensions developed by molds

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8
Q

What are the two structures of hyphae?

A

Septate and non-septate

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9
Q

What is an intertwined mass of hyphae?

A

Mycelium

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10
Q

What does the ability to grow dimorphically mean?

A

It means that in certain conditions, it can grow as either a yeast or mold. Yeasts are typically found in tissue and at 37C, while mold forms at room temp.

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11
Q

What 3 types of problems to fungi cause?

A

Allergies, mycotoxicoses (ie mushroom poisoning) and mycoses (true infections)

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12
Q

From least to most severe, what are the five classifications of bacteria?

A

Superficial mycoses, cutaneous mycoses, subcutaneous, systemic, opportunisitic

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13
Q

What is the most pathogenic category of fungal infections?

A

Systemic, while more deaths result from opportunistic because they are immunocompromised.

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14
Q

What is the main way of catching a systemic fungal infection?

A

Inhaling conidia or spores

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15
Q

Why has the incidence of mycotic patients increased within the last year?

A

We are keeping immunocompromised patients, like HIV patients, alive longer. Thus, they are exposed to more fungi.

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16
Q

What are three ways fungi can cross a barrier to cause infection?

A

Mechanical breaks, inhalation, invasive hyphae formation

17
Q

Why do normal healthy individuals have good tolerance of fungal infections?

A

Opportunistic molds are sensitive to neutrophils
T-cell immunity is of primary importance
Antibodies can play a role in preventing infxn
Much of the damage is from the immune response

18
Q

What is sabouraud’s medium?

A

A low pH, high glucose environment that promotes the growth of fungi while hampering growth of bacteria.

19
Q

What are some problems with antifungal drugs?

A

They target eukaryotes, so they are toxic

Many treatments fail or relapse

20
Q

What are common fungal targets of antifungal treatment?

A

Cell wall, ergosterol (fungal membrane), genome replication

21
Q

How are localized or superficial infections treated?

A

Topical cream or observation

22
Q

HOw are disseminated infxns treated?

A

Oral meds or IV