Interventions

Question 1

What is zero-order kinetics?

Answer 1

Constant amount of substance removed per unit time, regardless of concentration

Question 2

What is volume of distribution? (Pharmakokinetics)

Answer 2

Amount of drug absorbed into the body (dose/plasma)

Question 3

What factors affect endogenous clearance

Answer 3

Route of exposure, comorbidities, organ dysfunction e.g. toxin causing AKI may have reduced clearance

Question 4

When is extracorporeal therapy considered in terms of volume of distribution?

Answer 4

<1-2L/kg volume of distribution

Question 5

Haemodialysis = diffusive clearance, what is the toxin size appropriate? Water-soluble?

Answer 5

Through diasylate. Toxins that are 500-1000 Da, water soluble

Question 6

Haemofiltration = convection, toxin size? Water-soluble?

Answer 6

Solvent removed, cleared through solvent drag >1000-10,000 Da, better for protein bound toxins

Question 7

What is contained in intralipid?

Answer 7

20% primarily soybean fat emulsion

Question 8

MOA of intralipid?

Answer 8

Lipid sink decreasing bioavailability of lipid-soluble medications, delivering FFas to myocardium, stimulate voltage gated Ca channels, increased vasopressor effect (alpha adrenergic)

Question 9

MOA