Intermediate filament Structures

Question 1

Cytokeratin structural component of

Answer 1

Epithelial cells (keratin in desmosomes and hemidesmosomes)

Question 2

Desmin structural component of

Answer 2

Muscle cells (smooth, skeletal, heart)`

Question 3

Glial fibrillary Acid proteins structural component of

Answer 3

Astrocytes, Schwann cells, other neuroglia

Question 4

Neurofilaments L, M, H structural component of

Answer 4

axons within neurons
L, M, H refers to molecular weight
low, medium, high

Question 5

Nuclear lamins A, B, C structural component of

Answer 5

nuclear envelope and DNA within

Question 6

Vimentin structural component of and purpose

Answer 6

component: CT (fibroblasts, leukocytes, endothelium)
purpose: support cellular membranes, keep certain organelles fixed in cytoplasm

Question 7

Cytokeratin stain used to identify

Answer 7

Carcinoma

Question 8

Desmin stain used to identify

Answer 8

Rhabdomyosarcoma, Leiomyosarcoma

Question 9

Glial fibrillary acid proteins (GFAP) stain used to identify

Answer 9

Glioblastoma, Schwannoma

Question 10

Neurofilaments L, M, H stain used to identify

Answer 10

Neuroblastoma

Question 11

Vimentin stain used to identify

Answer 11

Sarcomas