inintro into pharmacokinetics

Question 1

how are majority of drugs taken

Answer 1

• orally
• they are dissolved in the stomach
• absorbed in the small intestine due to its large surface area

Question 2

drug must be able to cross eouthelial cells that like tissue

Answer 2

absorbtion occurs depending on the chemical properties of the compound
- passive diffusion
- paracellular
endocytosis
- action of drug transporter proteins

Question 3

how do the drugs move

Answer 3

through intestines and blood circulatory system
- delivered to liver and then to organs, then other compartments of the body

• elimination or clearence of drugs may be in their original form or after its metabolism into more water soluble/inactive tablets
• the main site of drug bio transformation is in the liver as it has large amounts of enzymes
  -exits the body through different secretion systems