Inherited Diseases

Question 1

Inherited neutrophil defects (6) and their breeds

Answer 1

Pelger Huet - Aust Shep, Autosomal Dom, homozygous lethal
Immature nucleus shape but no function defect

Birman cat Neutrophil Anomaly
- Magenta granules, normal function

Chediak Higashi Syndrome - Persian Cats (auto recessive)
- larged fused vacuoles, may have reduced platelet function
Mucopolysaccharoidoses - heritable LSD
Multiple phenotypic abnormalities, multiple dark magenta granules in neutrophils.

Canine Leukocyte Adhesion Deficiency (CLAD) - Irish Setter
Autosomal recessive
- Neutrophils fail to marginate and thus cannot enter tissues.

Trapped Neutrophil Syndrome - Border Collies
Autosomal recessive
- Cannot exit bone marrow resulting in neutropenia with left shift and monocytosis. Immunodeficient.