Influenza & AIDS

Question 1

How many RNA segments does the influenza virus genome possess?

Answer 1

8

Question 2

What is the function of the M2 influenza virus protein?

Answer 2

Ion channel embedded in virus envelope

Question 3

What, roughly, is the shape of the influenza virus?

Answer 3

Spherical

Question 4

Which influenza RNA segment encodes HA?

Answer 4

RNA segment 5

Question 5

What happens to the endosome containing the influenza virion following entry into the cell?

Answer 5

Acidification

Question 6

What is the structure of influenza HA?

Answer 6

Trimer

Question 7

What does each monomer of the HA trimer comprise?

Answer 7

HA1 and HA2 subunit

Question 8

How do influenza drugs amantadine and rimantidine inhibit virus entry?

Answer 8

Raise intracellular pH of vesicles; acidification of endosome required for influenza entry

Question 9

Which surface glycoprotein influenza virus required for its release?

Answer 9

NA to cleave sialic acid all over cell surface

Question 10

Neutralising antibodies against which influenza virus glycoprotein is most important?

Answer 10

HA - it is this subtype which changed between Asian and Hong Kong pandemic

Question 11

Name of subfamily to which HIV belongs?

Answer 11

Lentiviruses

Question 12

Which opportunistic fungal infection were homosexual men exposed during the 1980s emergence HIV?

Answer 12

Pneumocystis jirovecii (formerly carinii)