Infection and Immunity

Question 1

Expression of what cytokines induce the activation of Th1 T cells?

Answer 1

IL12, IFNy

Question 2

What cytokines are produced by Th1 T cells?

Answer 2

IL2, IFNy, TNF-a, which are proinflammatory

Question 3

Expression of what cytokines induce the activation of Th2 T cells?

Answer 3

IL2 and IL4

Question 4

What cytokines are produced by Th2 T cells?

Answer 4

IL4, 5, 6, 10, 13 which are anti-inflammatory

Question 5

Expression of what cytokines induce the activation of Treg T cells?

Answer 5

IL12 and TGFB

Question 6

What cytokines are produced by Treg cells?

Answer 6

IL10, IL35 and TGFB

Question 7

Expression of what cytokines induce the activation of Th17 T cells?

Answer 7

IL6 and TGFB

Question 8

What cytokines are produced by Th17 cells?

Answer 8

IL17, IL21, IL22

Question 9

What does the presence of Th17 suggest?

Answer 9

Chronic disease

Question 10

What is the function of Th1 cells?

Answer 10

Release pro-inflammatory cytokines that activate macrophages and cytotoxic T cells to mount an immune response and eliminate pathogens

Question 11

What is the function of T2 cells?

Answer 11

T2 cells are CD4 T cells that release anti-inflammatory cytokines that activate B cells, promote antibody production and inhibit macrophages to protect the body against damage after inflammation

Question 12

What is the function of Th17 cells

Answer 12

Th17 cells are CD4 T helper cells which release cytokines which can act as pro- or anti-inflammatory depending on the environment.

These cells can help against pathogens but are also implicated in chronic inflammation and autoimmune disorders

Question 13

What is the function of Treg cells?

Answer 13

Treg cells are WBCs that are important for regulating the immune response. They release inhibitory cytokines and promote the differentiation of M2 macrophages to dampen the immune response and protect against chronic inflammation and prevent autoimmune diseases.