Immunosupressants

Question 1

What are immunosupressants used for?

Answer 1

1. transplant surgery - induction/maintainance
2. Autoimmune and chronic inflammatory disorders (RA/SLE/psoriasis)

3

Question 2

Name 3 main problems wih immunosupression?

Answer 2

1. higher risk of infection/wound healing
2. Increases cancer risk
3. Reactivation of disease
   - HIV/HepB/C
   - TB

Question 3

What are the 4 main classes?

Answer 3

1. general immunosupression
2. calcineurin inhibitors
3. anti-metabolites
4. mTOR inhibitor
5. Purine synthesis inhibitor

Question 4

which drugs act by inhibiting gene translation and cytokine production?

Answer 4

1. corticosteroids
2. ciclosporin
3. tacrolimus

Question 5

which drugs act by inhibiting DNA replication and cell proliferation??

Answer 5

exert their immunosuppressive effects by reducing interleukin-2 (IL-2) production and IL-2 receptor expression, leading to a reduction in T-cell activation