Immunology & the eye Flashcards
What are the innate parts of the eyes immune system?
Blink reflex
Tears
What is contained within tears?
Lysozyme
Complement
Tear ipids
secretory IgA
What is the only part of the eye with lymphatic drainage?
Conjunctiva
What cells within the conjunctiva acts as antigen presenting cells?
Dendritic cells
What is immune privelege?
Certain sites of the human body are able to tolerate the introduction of anigens without elicitng an inflammatory immune response
What is sympathetic ophthalmia?
Rare granulomatous uveitis due to trauma or surgery
Does sympathetic ophthalmia affect one or both eyes?
Both (exciting eye & sympathising eye)
Which eye conditions are type I hypersensitivity reactions?
Acute allergic conjunctivitis
What is chemosis?
Oedema of conjunctiva
Which cells are responsible for direct cell killing in type II hypersensitivity reactions?
Macrophages/NK cells
Complements (MAC)
Example of eye condition with type II hypersensitivity reaction
Ocular cicatricial pemphigoid
Presentation of ocular cicatricial pemphigoid?
Blistering lesions around the eyelids and on surface of eye
Example of eye condition involving type II hypersensitivity reaction?
Autoimmune corneal melting
Example of eye condition caused by type IV hypersensitivity
Corneal graft rejection (vascularisation leads to rejection)
