Immuno Exam 1 Review

Question 1

HMGB1

High Mobility Group Box 1

Answer 1

molecule released from a necrotic cell and recognized as a danger signal by the immune system

Question 2

CRP

C- Reactive Protein

Answer 2

detects acute inflammation

can activate complement, but is not damage associated molecule

Question 3

Important defense for extracellular bacteria using adaptive immunity

Answer 3

B cells

Question 4

cytokine with potent chemoattractant activity strongly involved with cellulitis

Answer 4

IL-8

extracellular

Question 5

IL-1

Answer 5

systemic cytokine function,
has ability to form abscesses .
activation of fever.
can stay second in lineup to migrate into tissue and participate in acute phase proteins.

Question 6

the c3a is produced by an enzymatic cascade that activates the complement. what is the major functional role of this byproduct in immuno-inflammatory reactions mediated by completement?

a. formation of c3 convertase
b. promoting phagocytosis
c. triggering the alternative - pathway of complement
d. formation of c5 convertase
e. promoting chemotaxis of immune cells

Answer 6

e. promoting chemotaxis of immune cells

Question 7

IL-6

Answer 7

induction of acute phase proteins > inflammation

Question 8

alternative - pathway of complement

Answer 8

alternative is SPONTANEOUS activation of complement

Question 9

C3 DEFICIENCY causes

Answer 9

increased number of severe bacterial infections with extracellular bacteria

Question 10

which causes the symptoms of septic shock?

Answer 10

release of IL-1 and TNF into circulation

Question 11

What triggers the decay of C1 component upon the CLASSICAL activation of complement?

Answer 11

Antigen-IgG complexes

Question 12

Eosinophils

Answer 12

associated with parasitic/helminth infections.

Question 13

three days ago pt sustained cut. developed infectious sx. predominant cell type in blood is/are

Answer 13

juvenile and mature neutrophils

bone marrow working hard producing new ones and releasing mature cells.

Question 14

macrophages

Answer 14

activated cells to kill bacteria living in intracellular vesicles.
not in blood circulation - tissue cells

Question 15

the susceptibility to complement mediated damage is due to lack of the complement regulatory protein that is active in the cell membrane. malfunctioning which of the following complement components is most likely the causative factor in the pathogenic mechanics of the disease

a. properdin
b. factor I
c. factor B
d. C1q
e. factor D

Answer 15

b. factor I

only one involved in this particular aspect of complement.

Question 16

Defensins

Answer 16

• small proteins produced by circulating WBCs and epithelial cells
• have broad spectrum activity against gram positive and gram negative bacteria and kill a bacteria in number ways.
• part of innate immunity
• highly conserved with few variants
• contain a large proportion of arginine residues
• amphipathic, with hydrophobic and hydrophillic regions
• disrupt pathogen membranes by penetrating and disrupting integrity

Question 17

B cells

Answer 17

are activated to produce antibodies that eliminate or neutralize extracellular pathogens

Question 18

MHC class 1 molecules are important for

Answer 18

binding to CD8 molecules on T cells

Question 19

Virus derived proteins

Answer 19

The virus-derived peptides that bind to his HLA class I molecules also bind to his sister’s HLA class I molecules.