Immunity

Question 1

adjuvant

Answer 1

adjuvant

• any substance tt enhances immunogenicity of antigen
• can lead to adjuvant diseases (disseminated encephalomyelitis)
• Al hydroxide, silica particles
• Freund’s complete adj. - incomplete adj + killed tubercle bacilli
• used in vaccines

Question 2

graft-versus host reaction - defn., causes

Answer 2

graft-versus host reaction - defn., causes

the graft mounts an immune response against Ags of host

• graft has immunocompetent T cells
• recipient has transplantation Ag which are absent in graft

Question 3

graft-versus host reaction - c/f, egs

Answer 3

graft-versus host reaction - c/f, egs

• growth retardation, lymphoid atrophy
• anemia, diarrhea, emaciation
• hepatomegaly

egs: allograft in specific tolerance induced recipient

Question 4

IgG - defn,fn (7)

Answer 4

IgG

m/c, most daily pdn, most 1/2 life
1-4 subclass
monomer

fn:• crosses placenta - natural passive immunity
•complement fixing - activates classical pathway
•opsonization - enhance phagocytosis
•neutralization of toxins
•indicates c/c or past inf.
•co.aggl rxn of S.aureus
•anti-Rh IgG in delivery

Question 5

IgA - feature,

Answer 5

IgA

2nd m/c
monomer/dimer( secretory IgA)

ADCC -Ab dependant cell-mediated cytotoxicity
degranulation of immune cells

Question 6

Secretory IgA

Answer 6

secretory IgA

dimer
indicates local/mucosal immunity
in breast milk, tears, saliva
1,2 subclasses
secretory piece
activates alternative complement pathway
increase phagocytosis