Immune System

Question 1

How many classes of HLA exist?

Answer 1

There are three classes:

HLA I is found on all nucleated cells.
HLA II is found on antigen presenting cells.

Question 2

What is the difference in function between HLA class I and HLA class II?

Answer 2

HLA class one is the “self “molecule found on all nucleated cells. HLA class two is found on antigen presenting cells.

HLA I presents to CD8
HLA II presents to CD4

Question 3

What is the difference in function between Th1 and Th2 cells?

Answer 3

Th1 induces CD8 cells. Th2 induces B cells

Question 4

How are NK T cells and NK cells different?

Answer 4

NK T cells recognize lipid and glycolipds presented by CD1.

NK cells are always in KILL mode unless they are turned off by HLA-E on self cells.

Question 5

You are studying a cell that requires CD1 to function properly. What type of cell are you studying?

Answer 5

NK T cells

Question 6

True or false: B cells can act as antigen presenting cells.

Answer 6

True

Question 7

Regulatory T cells express FoxP3 controlling the immune system. What modulators are involved in this regulation?

Answer 7

IL – 10

TGF – b

Question 8

Which antibody types can activate complement?

Answer 8

IgG and IgM

Question 9

What are the three different complement binding pathways? On which complement step do they all converge?

Answer 9

Classical
Mannose binding
Alternative

C3a

Question 10

Which complement step triggers opsonization?

Answer 10

C3b

Question 11

Which complement step promotes inflammation, triggering chemotaxis, leukocyte activation, and mast cell degranulation?

Answer 11

C5a

Question 12

Which chromosome carries genes for human leukocyte antigens? (HLA)

Answer 12

Chromosome 6