ID AntiFungals

Question 1

Azoles Prototype Drug

Answer 1

Fluconazole

Question 2

Azoles MOA

Answer 2

Inhibits fungal wall synth via inhibition of ergosterol synth. CP450 enzyme inhibitor

Question 3

Azoles AE

Answer 3

Hepatotoxicity(rare)

Question 4

Echinocandins Prototype Drug

Answer 4

Caspofungin

Question 5

Echinocandins MOA

Answer 5

Weakens cell wall by inhibiting beta-(1,3)-glucan IV Exposes beta-glucan—-> exposes antigens for immune recognition

Question 6

Echinocandins AE

Answer 6

Elevated liver enzymes. Vomiting, diarrhea

Question 7

Griseofulvin Prototype Drug

Answer 7

Griseofulvin

Question 8

Griseofulvin MOA

Answer 8

Inhibits mitosis by binding tubulin and tubular proteins required for cell division

Question 9

Griseofulvin AE

Answer 9

CNS: Headache, peripheral neuropathy, sleep disturbances.
Dermatological: skin rashes (urticaria, lichen plants, erythema, photosensitivity, edema). Neutropenia (rare)

Question 10

Polyenes Prototype Drug

Answer 10

Amphotericin B

Question 11

Polyenes MOA

Answer 11

Nystatin: topical, Creates porous channels in fungal cell wall for hydrogen and potassium leakage by binding to sterols (Ergosterol, cholesterol)

Question 12

Polyenes AE

Answer 12

Amphotericin B: nephrotoxicity, infusion reactions(fever, chills, hypotn, vomiting, dyspnea, headache), electrolyte abnormalities(hypokalemia, hypomagnesemia)

Question 13

Pyramidine Antifungals Prototype Drug

Answer 13

Flucytocine

Question 14

Pyrimidine Antifungals MOA

Answer 14

na synth by inhibiting thymidylate synthase.
2. Prevents protein synth by incorporating into fungal RNA as 5-FU

Question 15

Pyrimidine Antifungals AE

Answer 15

GI, infection, Liver damage, toxic epidermal necrolysis

Bone marrow suppression (rare)

Question 16

Allylamine Antifungal Prototype Drug

Answer 16

Terbinafine

Question 17

Allylamine Antifungal MOA

Answer 17

Liver met Inhibits ergosterol production by inhibiting lanosterol(ergosterol precursor). Fungicidal

Question 18

Allylamine Antifungal AE

Answer 18

Stevens-Johnson syndrome(life threatening separation of dermis-epidermis), toxic epidermal necrolysis, liver failure, lupus, neutropenia/lymphopenia

Question 19

Quinolones (Antimalarial) Prototype Drug

Answer 19

Chloroquine

Question 20

Quinolones (antimalarial) MOA

Answer 20

metabol Unknown. Theorized to inhibit synthesis of nuclei acids and/or expose parasite to heme (toxic to parasite)

Question 21

Quinolones (Antimalarial) AE

Answer 21

GI, headache, pruritus, retinopathy, ototoxicity, CNS (seizures, psychosis), cardio
Primaquine: Hemolytic anemia, methemoglobinemia

Question 22

Anthelmintics (Worm Killers) prototype drug

Answer 22

Benzimidazoles

Question 23

Anthelmintics (worm killer) MOA

Answer 23

oles: disrupt microtubule formation. increase sol creases calcium influx = paralysis and death.
s nicotinic receptors. (prodrug): liver meta Ivermectin/Piperazine: promotes GABA = paralysis.

Question 24

Anthelmintics (work killer) AE

Answer 24

urticaria, agranulocytosis, alopecia, elevated hepatic enzymes

Question 25

Antiprotazoals Prototype Drug

Answer 25

Pentamidine

Question 26

Antiprotozoals MOA

Answer 26

Inhibits dna synth by inhibiting topoisomerase II(enzyme that cuts and reseals DNA strands) Interferes with RNA

Question 27

Antiprotozoals AE

Answer 27

cardio(hypotn, tachycardia), glucose abnormalities, renal/hepatic disfunction. N/v, abd pain, peripheral neuropathy, arthralgia, thrombophlebitis, encephalopathy. N/v, CNS (weak, myalgia, peripheral neuropathy), hypersensitivity