Hypersensitivity

Question 1

antibody with type I hypersensitivity

Answer 1

IgE

Question 2

antibody with type II hypersensitivity (2)

Answer 2

IgM or IgG

Question 3

antibody with type III hypersensitivity (2)

Answer 3

IgM or IgG

Question 4

cells with type IV hypersensitivity

Answer 4

T cells

Question 5

type I hypersensitivity is associated with _____ ; immediate reaction

Answer 5

allergies

Question 6

IgE live in blood for ____; once attached to mast cell lives ____

Answer 6

a day

several weeks

Question 7

_____ bought into tissue by signals from MAST cells, will ______ upon antigen exposure

Answer 7

basophils

degranulation

Question 8

mom has a strong bias towards ____ during pregnancy

Answer 8

Th2 cells

Question 9

type II hypersensitivity is _____ mediated

Answer 9

antibody

Question 10

complement INDEPENDENT cytotoxicity is called

Answer 10

antibody-dependent cell-mediated cytotoxicity (ADCC)

Question 11

in type I hypersensitivity, allergen enters body, _____ eats it, and presents peptide on MHC __, ______ T cells are activated, and differentiate into Th__, which activate ___ cells, which finally make ___ antibody (cause class-switching)

Answer 11

APC
MHC II
helper T cells
Th2
B cells
IgE

Question 12

in early phase of type I hypersensitivity, ___,____ and ____ chemistry released by MAST cell

Answer 12

vasoactive amine (histamine)
proteases
prostaglandins

Question 13

in late phase of type I hypersensitivity, ___ and ____ pull in other WBC’s

Answer 13

IL-4

TNF

Question 14

cells located in tissue

immediate response to allergy

Answer 14

mast cells

Question 15

• cells brough into tissue from blood by signals sent by mast cells
• also have receptors for IgE and will degranulate upon antigen exposure
• rapid response

Answer 15

basophils

Question 16

• cells recruited from bone marrow

- delayed response

Answer 16

eosinophils

Question 17

non atopic people mostly produce ___ antibodies, while atopic people produce ___

Answer 17

IgG

IgE

Question 18

lupus is example of type ____ sensitivity

Answer 18

type III

Question 19

MS is example ____ hypersensitivity, and ____ do most damage

Answer 19

IV

macrophages

Question 20

a type II hypersensitivity disease that uses antibodies to bind to TSH receptor on thyroid- excessive stimulation

Answer 20

grave’s disease