Hyperlipidaemia Flashcards
What level is hyperlipidaemia diagnosed at?
- 6 mmol/ml
What is total cholesterol for healthy adults
- 5mmol/ml
What is total cholesterol level for patients with other co-morbidities
- 4mmol/ml
Which drugs can cause hyperlipidaemia (4)
- Antipsychotics
- Immunosuppression
- Corticosteroids
- HIV medication
The 5 types of lipid regulating drugs?
- Statins
- Fibrates
- Ezetimibe
- Bile acid sequestrants
- Nictonic acid groups
How do statins work and when should they be taken?
- They work by reducing HMG-CoA reductase and they work at night
What dose of statins do you give to patients for prevention of CVD (
- Atorvastatin
o Primary prevention 20mg
o Secondary prevention 80mg
- Rosuvastatin 10mg OD
- Simvastatin 80mg ODFirst choice of drug if stains are contraindicated or not tolerated in patients with primary hypercholesterolaemia, familial hypercholesterolaemia and hyperlipemia.
- Ezetimibe
First choice of drug if stains are contraindicated or not tolerated in patients with moderate moderate hypertriglyceridemia
Fibrates
What is the side effects of statins (3)
Myopathy, Lung disease, Increase HBA1c
Which patient are at higher risk of muscle wasting (5)
- Hypothyroidism
- High alcohol intake
- Renal impairment
- History of muscle disorder
- Co-commitant use of statins and fibrates etc.
Which monitoring requirements need to be consider if patient is on statins? (4)
Which monitoring requirements need to be consider if patient is on statins?
When would you discontinue statin use
Signs of muscle weakness and SOB
Creatinine Kinase 5X the upper limit
LFT 3 times the upper limit
What is the ruling for statins in pregnancy
Teratogenic so stop
How many months before conceiving should the patient stop statins.
3 months
