HTN Flashcards
MOA diltiazem(cardizem)/verapamil(calan) for treating HTN
SA node and ventricular cardiac myocytes;
slows down the Ca2+ influx by Ca2+ voltage-gated channels;
causing a decrease in HR, CO, BP
MOA of triamterene-HCTZ (Dyazide, Maxide) for preventing K+ wasting
collecting duct;
blocking the reabsorption of Na+ by the Na+ ion channel and retaining K+;
preventing K+ waste
MOA of amlodipine (Norvasc) for treating HTN
arteriolar smooth muscle;
blocking Ca2+ influx by Ca2+ voltage-gated channels and downstream action of vasoconstrictors;
reducing PVR
MOA of Losartan (Cozaar)/Olmesartan (Benicar)/Irbesartan(Avapro)
vascular smooth muscle and adrenal gland;
blocking AT1 receptor and decreasing vasoconstriction and aldosterone;
reduces SV. PVR and BP
MOA of felodipine, amlodipine(Norvasc), Nifedipine(Procardia) that induces peripheral edema
dilation of arterioles;
increasing capillary pressure and leading to fluid leakage
MOA of lisinopril(zestril), quinapril(accupril) in increasing serum creatinine levels
glomerular efferent arterioles;
dilation decreases the glomerular filtration pressure allowing more creatinine to not be filtered in the glomerulus
MOA of HCTZ(Esidrix)/Chlorthalidone(Hygroton, Thalitone)
distal tubule;
blocking the Na+/Cl- transporter decreasing the absorption of Na+ and H2O;
reducing SV, CO, and BP
MOA of spironolactone(Aldactone)
collecting duct;
competes with aldosterone for mineralocorticoid receptor binding and reduces Na+/H2O absorption while retaining K+ and decreasing vasoconstriction;
reducing PVR, SV, CO, and BP and preventing K+ waste
MOA of aliskiren
blood vessel;
competitively inhibits angiotensinogen to form Ang1 by binding to renin; decreasing the synthesis of Ang2;
reducing PVR, CO, and BP
MOA of lisinopril(Prinivil)/benazepril(Lotensin)
blood vessel;
competitively inhibits Ang1 to Ang2 by binding to ACE reducing vasoconstriction and aldosterone;
reducing PVR, CO, and BP
MOA of ACE degrading bradykinin
blood vessel;
competitively inhibits Ang1 to Ang2 by binding to ACE which will block the degradation of bradykinin causing an increase in bradykinin; increasing vasodilation leading to a dry cough
MOA of metoprolol(lopressor/toprol)
SA node and cardiac myocytes;
blocking stimulation of the beta 1 receptors;
causing decreased HR and contractile force;
reducing CO, PVR, and BP
MOA of Carvedilol(Coreg)/Labetalol
arteries and veins;
blocks stimulation of the alpha 1 and beta 1&2 receptors causing vasodilation;
reducing CO, PVR, and BP
MOA of Clonidine (Catapres)/Methyldopa
Brainstem;
binds the alpha 2 receptor blocking SNS outflow;
reduce CO and PVR
ACEi that are eliminated by the kidney and liver
benazepril (lotensin)
ramipril (altace)
fosinopril (monopril)
trandolapril
