HODGKIN LYMPHOMA Flashcards
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What is the most common type of Hodgkin Lymphoma (HL)?
Classical Hodgkin Lymphoma (cHL), accounting for 95% of HL cases.
What are the histological features of Classical Hodgkin Lymphoma (cHL)?
Presence of Reed-Sternberg (RS) cells in an inflammatory background.
What is the immunophenotype of cHL?
CD30+, CD15+, CD45-, PAX5 weakly+.
What age groups are commonly affected by cHL?
Adolescents, young adults, and the elderly.
What is the most common subtype of cHL?
Nodular Sclerosis Classical Hodgkin Lymphoma (NS cHL).
What are the histological features of Nodular Sclerosis cHL?
Nodular growth with fibrous bands and lacunar variants of RS cells.
What is the common age group for Nodular Sclerosis cHL?
Adolescents and young adults.
What is the Mixed Cellularity subtype of cHL associated with?
HIV and Epstein-Barr virus (EBV) infection.
What are the histological features of Mixed Cellularity cHL?
Mixed inflammatory infiltrate with RS cells.
What is the immunophenotype of Mixed Cellularity cHL?
CD30+, CD15+, often EBV+.
What age groups are affected by Mixed Cellularity cHL?
Children and older adults.
What is unique about Lymphocyte-Rich cHL?
It is a rare subtype with a better prognosis.
What are the histological features of Lymphocyte-Rich cHL?
Nodular or diffuse growth with abundant lymphocytes and few RS cells.
What is the immunophenotype of Lymphocyte-Rich cHL?
CD30+, CD15-, CD45+ (sometimes).
What is the common age group for Lymphocyte-Rich cHL?
Adults.
What is the Lymphocyte-Depleted subtype of cHL associated with?
Aggressive disease, advanced stage, and often HIV-positive individuals.
What are the histological features of Lymphocyte-Depleted cHL?
Numerous RS cells with few reactive lymphocytes.
What is the immunophenotype of Lymphocyte-Depleted cHL?
CD30+, CD15+, often EBV+.
What is Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL)?
A distinct subtype with a different immunophenotype and clinical course.
What are the histological features of NLPHL?
‘Popcorn’ or LP (lymphocyte-predominant) cells.
What is the immunophenotype of NLPHL?
CD20+, CD45+, CD15-, CD30-.
What is the common age group for NLPHL?
Young adults, with males more commonly affected.
What are the genetic abnormalities in Hodgkin Lymphoma?
Mutations and amplifications in NF-kB pathway genes (REL, NFKBIA) and immune checkpoint genes (PD-L1, PD-L2).
