Hennoch-Schönlein Purpura (IgA Vasculitis)

Question 1

Definition/Pathophysiology

Answer 1

Deposition of IgA deposition in blood vessels

Question 2

Etiology/Pathogenesis

Answer 2

Changes in IgA1 O-glycoforms (heavier)
Association between mucosal infection
Common 3-15Y
10% will develop kidney failure

Question 3

Clinical Features

Answer 3

Palpable purpuric rash (usually extensor Surfaces; sparing of the trunk and face)
Athritis/ arhralgia (polyathralgia, transient and migratory)
Kidney disease
Abdominal pain

Skin biopsy—> leukocytoplastic vasculitis

Question 4

Therapy

Answer 4

Pusled methylprednisolone
Followed by 3month prednisolone