hemostasis

Question 1

platelet function

Answer 1

1) exposed collagen
2) platelets release ADP and thromboxane A2
3) platelets adhere to area of injured endothelium mediated by von willebrand factor

Question 2

secreted granules

Answer 2

1) dense
- ADP, ATP, serotonin, Ca++
2) alpha granules
- PDGF, fibrinogen, VWF, platelet factor 4 (coag cascade), etc.

Question 3

platelet interactions and signaling

Answer 3

1) COX2 for platelet function
- arachidonic acid => prostacyline or thromboxane A2
2) dipyridamole inhibits phosphodiesterase
- calms platelets to resting state
3) clopidogrel inhibits binding of ADP
4) abxicimab inhibits binding of fibrin
5) aspirin is irreversible ibuprofen is reversible
- inhibit platelet COX and TXA2

Question 4

aspirin

Answer 4

1) both antiinflammatory and anticoagulant
2) not recommended for primary cardiovascular prevention
3) reommended for secondary prevention

Question 5

laboratory tests

Answer 5

1)