Hemolytic Anemias

Question 1

-Recessive trait resulting in abnormal Hgb and RBC cell shape -Hemolytic Anemia -Jaundice, splenomegaly, LE ulcers

Answer 1

Sickle-Cell Anemia

Question 2

-IgG binds RBC–> conformational change–> trapped in spleen -Fatigue, dyspnea, splenomegaly

Answer 2

Autoimmune Hemolytic Anemia

Question 3

-RBC spherical not biconcave -Results in hemoloysis from trapping of RBCs in spleen and their subsequent removal -Anemia not always present

Answer 3

Hereditary spherocytosis

Question 4

-Hereditary enzyme defect–>Hgb denatures-> RBC removed in spleen–>Episodic hemolytic anemia -Usually asymptomatic, but can flare with infection or exposure to drugs -More common in AA -Heinz Bodies

Answer 4

G6PD Deficiency

Question 5

-RBCs lysed by complement -Episodic hemoglobinuria

Answer 5

Paroxysmal nocturnal Hemaglobinuria