Heme/Onc

Question 1

sideffects of cisplatin

Answer 1

neurotoxicity, nephrotoxicity, tinnitus and hearing loss, severe nausea/vomiting, electrolyte abnormalities

Question 2

painless blisters, increased skin fragility on the dorsal surfaces of the hands, facial hypertrichosis, and hyperpigmentation

Answer 2

porphyria cutanea tarda; can be triggered by ingestion of things likek ethanol or estrogens; a deficiency of uroporphyrinogen decarboxylase enzyme in the heme synthesis pathway; elevated urinary porphyrin levels confirm the diagnosis; phlebotomy or hyroxychloroquine can provide relief; associated with patients with HepC

Question 3

Tx of hairy cell leukemia and its side effects

Answer 3

Cladribine, neurological and kidney damage

Question 4

tx of CLL

Answer 4

chlorambucil and prednisone

Question 5

Tx for non-Hodgkin’s lymphoma

Answer 5

CHOP regimen

Question 6

what to do with testicular cancer

Answer 6

resect first then figure out what it is later to figure out chemo needs; needle biopsy contraindicated due to possible spread of cancer cells through biopsy