Head and Neck Flashcards

1
Q

DDx Cervical Lymph Node?

A

Infection, Lymphoma, Mets

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2
Q

HPI for Cervical Lymph Node?

A

URI, sore throat, TB exposure
HIV, B symptoms
h/o cancer, XRT, thyroid sx, previous surgeries

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3
Q

Imaging for Cervical Lymph Node?

A

CXR infectious or malignant if positive get CT neck and chest
US guided FNA
PET if recurrent dz or met activity

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4
Q

What is Tx based on for a Cervical Lymph Node?

A

Benign (clear h/o sore throat or URI)-
observe for several weeks possible ABX and if persist w/u and remove
Lymphoma (can be dx based on FNA but still needs excision for final path confirmation),
stage it! CT N/C/A/P + BM bx (stage 4)-> CHOP
SCC- (See below for more exhaustive detail)
(2 Tests before any surgery!) CXR and Panendoscopy, CT H&N, if found excise primary site and MRND and 5000 rads
if still negative put patient to sleep -> direct laryngoscope c random bx of suspicious tissue (nasopharynx, base of tongue)
nothing - assume is mets and perform a radical neck dissection and give 5000 rads to entire neck
adenocarcinoma from (Broad-thyroid, lung, breast, salivary glands, prostate, GI) -
EXTENSIVE w/u all and if none is found including ER/PR and Mucin -> MRND, give 5000 rads (entire neck?) XRT and follow
if primary is found = Stage 4 dz and chemo may be offered

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5
Q

Describe a MRND?

A

create skin subplatsymal skin flaps
locate and protect mandibular (parallel to lower border of mandible) and cervical branches when creating superior flap
commence in posterior triangle anterior to trap removing areolar and lymphatic tissue
divide external jugular vein ) posterorinferior corner of dissection)
attempt to save the spinal accessory nerve unless involved with tumor
continue along anteriorly superiorly to the clavicle
ID phrenic nerve on anterior scalene b/w brachial (laterally) and IJV (medially and inside the carotid sheath ligate close to clavicle and avoid thoracic duct left side) , severing the omohyoid muscle to to provide better exposure and dividing SCM
divide anterior facial vessels as dissection heads superiorly
ID hypoglossal crosses 1 cm above the carotid bifurification
also ID lingual nerve and salivary duct to facillitate removal of submental and submandibular triange
remove contents of sub mental and submandibular triangles
Ligate submax duct
leave drains

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6
Q

Neck Mass DDX?

A

LN, primary neck tumor, congenital mass, sarcoidosis

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7
Q

Neck Mass HPI?

A

Hx- Very Important ! age of patient, duration, location, palpation
age
Hx- smoker, previous cancers, surgeries, URI, B symptoms, XRT

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8
Q

Neck mass Significance of age, location and timing

A

age
young patients- congenital, lymphadenitis, leukemias and lymphoma
middle aged- lymphoma, primary neck tumors
Elderly-Neoplastic
Location
over LN- enlarged LN,
Carotid bifurication- carotid body tumor
over anterior border of SCM- branchial cyst;
midline above thyroid- Thyroglossal cyst
midline, submental and firm- dermoid cyst
Posterior triangle, cystic- cystic hygroma
duration
few weeks- infectious vs few months to years - congenital or neoplastic

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9
Q

Neck mass PE?

A

PE- complete H&N, ENT, skin lesions, scars, LNs, liver & spleen, B sx,
how it feels, color

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10
Q

Neck mass test? and Labs?

A

U/S - cystic? solid?
FNA if vascular –> MRI
still no then pan-endoscopy (bronch, upper endoscopy, colonoscopy)
CXR, abdominal CT, PET
labs- CBC, +-TFT, calcitonin, calcium
if lymphoma needs core or excisional biopsy
Older age and + risk factors- CT H&N

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11
Q

Treatment of congenital neck tumors?

A

Congenital- usually young
Carotid body tumors, ganglionomas, schwanommas, cystic hygroma (posterior triangle, young), teratoma, branchial cyst = Tx local excise
Hemangioma -Observe; capillary or cavernous, AVMs—>embolize then excise
Branchial Cleft Cyst
1st cleft- open at angle of mandible, passes through facial nerve
2nd cleft- open anterior of the SCM passes b/w carotid bifurication
3rd cleft- open at lower border of SCM, passes behind carotid
Thyroglossal cyst (if infected, growing or concerned)—>sistrunk procedure
(transverse incision over mass, dissect off strap muscles, follow sinus tract down to base of tongue, include middle hyoid bone c specimen)

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12
Q

Treatment of cancer and sarcoidosis of the neck?

A

Cancer (mostly elderly patients)
Adenocarcinoma, SCC, BCC, sarcoma, melanoma (Needs SLNB), Testicular = resection of primary (if known) +- MRND, XRT
Lymphoma = staging CT scan, BM bx= stage I,II ->XRT; stage III,IV —>CHOP
Sarcoidosis
young black female c joint pain, CXR (b/l patchy), path - noncaseating granuloma, Tx- Steroids

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13
Q

RF for SCC of the Oropharynx

A

RF- ETOH, Smoking, other lesions removed

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14
Q

PE for SCC of the Oropharynx

A

Bimanual palpation, visual inspect, indirect laryngoscopy, LN

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15
Q

Staging and treatment for those stages of SCC of the Oropharynx

A

Stage 1 = 5 mm margins
Stage 2 = 2-4cm —>1 cm margins
Stage 3 = >4cm or node positive wide margins >1cm , MRND, 5000 rads
Stage 4 = distant mets- neoadj chemo and radiation
For stage 1 or 2 single modality surgery or radiation depending on how accessible it is (ex vocal cords) anterior vs posterior
If lesion not accessible (oral posterior, tonsils) then 6000 Rads and rebiopsy for residual tumor
Stage 3 or 4 combined modality (if involved LN to neck should get XRT to ENTIRE neck)

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16
Q

Treatment for SCC of the Oropharynx

A

For stage 1 or 2 single modality surgery or radiation depending on how accessible it is (ex vocal cords) anterior vs posterior
If lesion not accessible (oral posterior, tonsils) then 6000 Rads and rebiopsy for residual tumor
Stage 3 or 4 combined modality (if involved LN to neck should get XRT to ENTIRE neck)
consider doing just agree full thickness skin graft behind ear or base of neck
wedge resection of lip c 0.75 - 1 cm margins if total less 1/3 of length of lip if larger than advancement flap
XRT
medial canthus of eye or nose
5000 rads if close margins

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17
Q

Salivary Gland PE and HX?

A

mass at angle of mandible in front of ear
not tender or is it painful?, no smoking
PE if roll mass over the mandible if it sinks under likely a LN
assess facial nerve function! (runs right in b/w the parotid)

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18
Q

Salivary Gland testing?

A

FNA differentiate epithelial vs non epithelial

epithelial (Mixed, Warthin, Adenoma) vs non epithelial (cyst, LN, Hemangioma, Lipoma) —>get a high res US

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19
Q

Salivary gland imaging?

A

CT scan- det depth, size, invasion, LN enlarged

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20
Q

Salivary gland surgery?

A

Superficial parotidectomy c FS (low or high grade?)
malignant low grade- total parotid +- post op XRT
malignant high grade- radical parotid +MRND +postop xrt

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21
Q

Salivary gland consent?

A

Superficial Parotidectomy

preop consent- facial nerve injury, Freys syndrome, salivary fistula

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22
Q

Borders of a parotid gland resection?

A

Anatomic borders of parotid:
ant- mandibular rami
post- tympanic portion of temporal bone and mastoid process,
sup by external acoustic meatus, zygomatic arch, TMJ.

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23
Q

Describe a parotidectomy for salivary gland tumor?

A
  1. Don’t use paralytics, and have nerve stimulator
  2. Preauricular incision following angle of mandible (Mod Blair)
  3. Raise subplatysmal flaps
  4. Identify and save main trunk of greater auricular nerve divide branches that go into parotid
  5. Divide posterior facial vein but save retromandibular vein (prevents venous engorgement)
  6. As dissection cont anteriorly peripheral branches of facial nerve appear. Dissect superficial to them and spare them!
  7. Mobilize anterior border of SCM develop plane b/w muscle and mastoid
    divide the temporoparotid fascia
  8. Expose main trunk of facial nerve inferior to membranous portion of external auditory canal. (styloid process is deep and post belly of digastric is superficial)
  9. Trace trunk of facial nerve into parotid and dissect branches distally.
  10. Remove superficial lobe of parotid by dissecting in plane of nerve. (Nerve is b/w superficial and deep lobe)
    Send frozen and if benign you are done
    II. Close over drain.
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24
Q

Malignant Salivary gland parotid treatment?
Tumor adherant to nerve?
Massive tumors involving facial nerve with paralysis pre op?
suspicious nodes or high grade lesion?

A

Malignant-Complete conservative parotidectomy (spare facial nerve and branches)
-Tumor adherent to nerve- dissect off nerve and radiation 5000-6000 gy
-Low grade tumor involving portion of facial nerve treat with subtotal parotidectomy with preservation of uninvolved branches
-Massive tumors involving facial nerve with paralysis pre op can sacrifice nerve.
If nerve worked preop then attempt nerve graft -
MRND if suspicious nodes or high grade lesion they tends to metastasize.

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25
Q

ID facial nerve in Salivary gland tumor?

A

ID facial nerve -
ext auditory canal cartilage (Superficial) - nerve is 1 cm deep and inf to the tip
posterior belly of digastrics m (Superficial )- nerve is deep to it
Styloid process (d
eep)- nerve is superficial to it

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26
Q

facial n branches and treatment for severed?

A

facial n branches- The Zebra Bit My Cat - temporofrontal (eye brow lift procedure), Zygomatic (lateral torsoraphy to close eye), Buccal (nothing, min dysfunction), Mandibular (need to sever contralateral if injured) Cervical (platsyma)
facial injured- c/s PRS immediate repair, microscope, collagen tube c silicone glue 10 prolene

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27
Q

Frey Syndrome?

A

Freys Sx- rarely needs tx, botox, raise flap of skin and put facia or allured under the flap

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28
Q

Thyroid Nodule (palpable) ddx?

A

DDx- cyst, adenoma, hyperplastic nodules, thyroiditis, cancer papillary, follicular, medullary, Hurthe, anaplastic

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29
Q

Thyroid Nodule (palpable) PE

A

PE-Have pt swallow, does it move up and down c thyroid cartilage (thyroglossal duct cyst moves up and down c swallowing as well as tongue protrusion), compressive sx, mobility, size, LNs, hard, fixed, Phebertons sign (facial plethora, neck vein distension, dyspnea thoracic inlet obstruction)
>1 cm nodule is significant

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30
Q

Thyroid Nodule (palpable) HPI?

A

Hx- h/o XRT, FHx, Thyroid hx, onset of sx, dysphagia, dysphonia, hoarseness, MTC (diarrhea/flushing), hyper/hypothyroid sx, Thyroiditis (Cold, cough,URI)
rapid growth and new onset hoarseness- concerning

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31
Q

Thyroid Nodule (palpable) work up?

A

Blood test
TSH and if abnormal get thyroid fxn test, T4
Thyroid Antibodies anti-peroxidase, anti-thyroglobulin (r/o thyroiditis)
thyroglobulin (imp for f/u)
calcitonin/calcium (if suspect Medullary cancer (from hx) or parathyroid (elevated calcium)
If low TSH –> diff Graves vs toxic nodule via thyroid scintigraphy which will be High uptake in Graves
U/S is IOC for a newly dx nodule (size, location, LN) susp for malignancy (hypoechoic, irregular, extracapsular)
TSH elevated or normal - U/S FNA (FNB is tech a delicate procedure try not to mention it) avoid FNA in Graves can cause thyroid storm

32
Q

FNA results of Thyroid nodule and next step?

A

FNA
Fluid- clear - observe; clear but doesn’t disappear- FNA again or hemithyroidectomy; Bloody- send off and do hemithy
Solid
Benign 70% - F/U US 6mo
Goiter - see below
Non dx or Atypia or follicular lesion of undetermined significance - Repeat FNA
Follicular Neoplasm 15% -Lobectomy c only permanents because frozens unreliable
Suspicious malignancy - Lobectomy with frozens or total thyroid
Malignant - Total thyroidectomy
Medullary (amyloid on FNA)- total thyroidectomy and elective central LND +ipsilateral MRND

33
Q

Treatment for follicular, anaplastic, papillary, graves, toxic and non toxic solitary nodule, multinodular?

A

Follicular cancer /Hurthle Cell (more aggressive and doesn’t respond to I131)on final path —> total thyroidectomy (don’t do frozen)
Papillary frozens are OK for pap —> Total thyroid (easier to monitor and treat with a total postoperatively i.e. postop I131 and scanning)
central node dissection is better than cherry picking if palpable nodes
Graves -Tx
Total>RAI>PTU
Toxic Solitary Nodule -Tx
Lobectomy>RAI
Non-Toxic Nodular Goiter- Tx
thyroxin suppression for six months if nodule persist or enlarges —> hemithyroidectomy
Toxic Multinodular goiter - Tx
Subtotal >RAI
Anaplastic - Tx
Adriamycin , XRT 3wks, debulking surgery-almost always lethal usually not resectable and mets- D/W pt tracheostomy

34
Q

preop of graves?

A

2 weeks of PTU, Lugols for 10 days, Propanolol to ctrl HR

35
Q

Describe Thyroidectomy and subtotal

A

Thyroidectomy-
extend neck, consider nerve stimulator
transverse cervical incision
raise flaps
incise median raphe and mobilze strap muscles
ID medial vein ligate and divide look out for (RLN posterior)
ID and mobilze superior pole ligate and divide vessels (External SLN Cricothyroid mm)
ID and ligate inferior pole vessels medial —>lateral (watch out for RLN) near Ligament of Berry close to inferior pole (right loops around the Subclavian artery)
ID and protect Parathyroids
Divide Berrys ligament mobilizing the thyroid from trachea
mobilize isthmus and pyramidal lobe
Contralateral side
close strap muscles, and platysma don’t leave drain (unlike parotid)
Subtotal - leave some thyroid and the inferior and superior poles to help avoid nerve on occasion I have left tissue on top of the trachea by going through the substance of the gland with a small hemostat curved side up down avoid injury the RLN

36
Q

Complications of thyroid surgery and treatment

A

inadvertant parathyroid injury transfer to SCM
Nerve intrapped in tumor the nerve should be sacrificed
Hyperthyroid crisis fever, tachy , respiratory arrest and coma,
tx NS bolus, versed, Lugols, PTU Hydrocortisol, propanolol, O2, Tylenol
inadvertant RLN injury during thyroid surgery should stop the resection of the other half (assume midline position and retract later)

37
Q

Post op thyroidectomy? And followup?

A

24hrs postop admission to monitor for HTA, Hypocalcemia minimized with oral calcium supplements and d/c after 1 week
F/U Tx- start T3 Synthroid 0.125 mg , follow TG and TSH levels, after surgery stop T3 so TSH can rebound and perform I121 scan to detect residual tumor and if there is —> I131 ablation
repeat scans and if still there then reexplore and excise and ablate

38
Q

Non-Toxic Benign Goiter causes?

A

defective thyroxin synthesis which the pituitary then secretes more TSH, so increase in gland size but euthyroid
some develop hypothyroidism

39
Q

Non-Toxic Benign Goiter work up?

A

thyroid profile, US to r/o nodule, FNA can give path confirmation of benign goiter and r/o cancer in nodule (rare)
Need TRH stim test (rarely done anymore) to see how they respond and if they do —> synthroid
TFTs repeat bx in 6 mos and repeat evaluation- if toxic on labs then PTU

40
Q

Non-Toxic Benign Goiter treatment?

A

Most patients get I131 usually 50% reduction by 12-18 mo
(RAI only works on functioning tissue and most non toxic goiters are nonfunctioning so really doesn’t work)
Surgery reserved for compressive sx, suspect malignancy, thyrotoxicosis, cosmesis, TRH unresponsive, failed thyroxin for 1 yr
Subtotal thyroidectomy
no special prep for euthyroid

41
Q

Hyperthyroidism ddx

A

Causes- Diffuse goiter (Graves), nodular goiter, adenoma, thyroiditis

42
Q

Hyperthyroidism HPI and PE

A

Dx- made by symptoms ( palpitation, heat loss, weight loss, good appetite , fine tremors)
PE- hyperreflexia, tachy, a fib, sweating, thyroid enlarged

43
Q

Hyperthyroidism w/u

A

Thyroid profile-Free T4, TSH, TSI, anti TPO, anti TG
high resolution US No FNA can cause hyperthyroidism crisis unless nodule
I123

44
Q

Hyperthyroidism treatment

A

Radioactive I131 MC 1-2 doses, slow treatment, high chance of hypothyroidism, no pregnancy for 1 yr, good for elderly
Surgery- total thyroidectomy
indications - children or women who are or will be pregnant
compressive symptoms
presence of thyroid nodule (unable to r/o cancer)
failure of meds tx after 1-2yrs
cosmesis
Meds
PTU and Tapazole
Surgery prep for Graves
PTU until day of surgery
lugols solution (iodine) 2 cc TID for 10d preop
Inderal for tachycardia

45
Q

Hyperthyroidism crisis Sx and Tx?

A

(hyper metabolic state can quickly develop into respiratory arrest , coma (fever, and cardiac arrythmias)
IV fluid, Sedation, Lugols (blocks thyroxin), PTU, Hydrocortisone, Inderal, Antipyretics, O2

46
Q

F.U treatment for graves?

A

F/U thyroxin for life by TSH levels

47
Q

Papillary Thyroid Carcinoma surgery with questionable parathyroid

A

autograft any PT gland that have questionable viability; PT gland must be reduced to pieces that can survive on the diffusion of nutrients temporarily while neovascular growth occurs in weeks

48
Q

Papillary Thyroid Carcinoma prognosis

A

GAMES- gender, age, mitosis, extra capsular invasion, size
Age is the most important
Worst for males

49
Q

Papillary Thyroid Carcinoma w/u

A

US FNA - solid, hypo echoic nodule larger than 10 mm
Nuclear thyroid scintiscan only if TSH suppressed
Preoperative US to evaluate central and lateral cervical LN is required
lateral neck node c TG of the aspirate can determine the presence of mets papillary thyroid carcinoma then need neck dissection 2,3,4,6

50
Q

Papillary Thyroid Carcinoma complications

A

RLN paresis usually resolves days to months; if unilateral if permanent then palliation of the cord immobility and voice changes cane be achieved by vocal cord injection or larynoplasty
mild hypocalcemia c tingling, oral calcium 500-1500mg PO BID-QiD
more extreme - IV calcium gluconate

51
Q

Additional treatment for papillary thyroid carcinoma

A

Papillary thyroid cancer can concentrate iodine can deliver RAI over several weeks best when TSH is elevated (remove gland or administer recombinant TSH)

52
Q

Medullary Thyroid Cancer HPI and PE

A

Flushing, diarrhea, FHx, (Stones, Moans, Groans etc to r/o PT problems)

53
Q

Medullary Thyroid Cancer w/u?

A

U/S and FNB will demonstrate MTC
Calcitonin, CEA, Calcium, RET gene testing not MEN
other labs - urine and plasma metanephrines to r/o Pheo, PTH to r/o PT
r/o Pheo MEN2A (Parathyroid Hyperplasia, Pheo, MTC)
mets w/u
Check a CT scan A/P once cancer is established 2/2 to mets

54
Q

Medullary thyroid cancer with RET surgery?

A

1st resect —>Pheochromocytoma 2nd —> thyroidectomy

55
Q

Surgery for Medullary thyroid cancer in description

A

total thyroid and Px central neck (level 6) and if LN mets –> lateral neck dissection 2,3,4,6 hockey stick incision
transverse incision below cricoid
total thyroidectomy
central neck dissection ID RLN and remove fibroadipose tissue b/w two carotid sheaths from hyoid sup and Brachiocephalic vessels inferiorly
LN tissue anterior and posterior triangles defined by submandibular gland superiorly the IJ vein medially , traps laterally and clavicle inferiorly is removed
avoid injury to brachial plexus or phrenic nerve
medial aspect of SCM is reapprx to sternothryroid muscle, followed by platysma

56
Q

Describe a MRND? Borders?

A

MRND
borders - sup- digastrics, Post- CN 11, Inferiorly- thoracic inlet inferiorly
hockey stick incision- transverse cervical c vertical extension along border of trapezius on neck (avoid carotid vessels)
raise subplastymal flaps
ID protect marginal mandibular nerve located inferior margin of mandible (danger during superior flap) be careful inferiorly of phrenic nerve on left be careful of thoracic duct
mobilize SCM laterally and strap muscles medially
dissect level 6 nodes off jugular vein and
dissect level nodes 5 b/w SCM and trapezius
dissect level 2/3 superiorly to the mandible
take level 6 nodes

57
Q

Complications of MRND? and treatment?

A

Complication
ID injury to thoracic duct intraop - ligate with prolene
ID thoracic duct injury postop- milky white high TG place pt on fat free diet, abx, pressure dressing if not resolved then OR for ligation
HTA , tracheal compression open immediately at bedside followed by reoperation to evaluate cause of bleeding

58
Q

F/U for Medulary thyroid cancer

A

F/U
calcitonin and CEA 6mo then yearly after 2 x
Place on synthrod
Px
RET gene total thyroidectomy and central LND childhood

59
Q

Hyperparathyroidism DDx

A

DDx-
malignancy,
primary hyperparathyroidism (Adenoma (usually single)&raquo_space;hyperplasia, Ca),
secondary (renal failure),
Benign Familial hypocalciuric hypercalcemia, thiazide

60
Q

Hyperparathyroidism PE

A

present with a lab value increase in ca or depression and fatigue, 5th- 6th decade
hx- stones, bones, moans, psych overtones
PE-chovsteck signs, trousseaus (carpal spasms)

61
Q

Hyperparathyroidism w/u

A

always repeat the calcium level no matter what they give you
Calcium, PTH, 24 hr urine ca to r/o BFHH (its usually low), Alk Phosp (high will indicate good possibility for bone hunger post op)
iPTH, creatine, vit D determine if non parathyroid mediated
Localize- U/S and Sestembi scan of neck and mediastinum
reop- selective angiography
DEXA scn

62
Q

Function of PTH?

A

PTH - increases osteoclastic, stimulates renal calcium absorption

63
Q

Indications for surgery of hyperparathyroidism?

A
indications for tx
Cancer
Sx
calcium >11.5
decreased creatine clearance
T score
64
Q

Surgery for hyperparathyroidism description?

A

Surgery
First send baseline PTH and calcium level
supine neck externsion
4-5 cm transverse cervical incision
subplatsymal flaps to thyroid cart, SCM, substernal notch
divide straps along median raphe and dissect off lateral thyroid lobes
start with the lobe that was localized o/w start c right lower PT (MC for adenoma)
ID RLN and ITA
mobilize thyroid lobe medially
ID PT gland usually in thyrothymic tract anterior to the RLN and inferior to thyroid lobe
next ID Superior PT gland usually 1 cm of the RLN as it enters cricoidthyroid membrane and posterior to the thyroid lobe
ID all 4 glands especially if doing 3 1/2 gland excision prior to excision of abnormal gland (if questionable PT tissue can do bx or aspirate send IO PTH to confirm PT tissue and excise abnormal gland
after adenoma excision send IO PTH if drops by 50% w/in 15 minutes or back to normal close. Half life is 3.5 min PTH

65
Q

Multigland hyperplasia hyperparathyroidism treatment?

A

leave a normal sized remnant (usually for sporadic), or total with implantation to brachioradialis muscle in forearm (MEN)
if removing 3 1/2 glands, always start out with removing half of the first gland you ID and observe it . if it becomes ischemic, repeat the procedure with the second gland, and so on. have to preserve blood supply

66
Q

Parathyroid cancer treatment?

A

found incidentally intrapoeratively en bloc resection with ipsilateral thyroid lobe and central compartment LN is appropriate

67
Q

Parathyroid cancer with mets treatment?

A

palliative resection and bisphosphonates and calcimimetics, chemo and XRT rarely effective
Calcitonin acts quicker where bosphosphinates ca take a while

68
Q

Missing parathyroid? Still cant find it?

A

Missing parathyroid
retropharyngeal space
carotid sheath open from the level of the carotid bifurcation to base of neck
inferiorly- check thymus gland should be exposed (thymectomy)
intrathyroid PT tumor should be considered
all four glands found but still high PTH suspect a 5th PT gland
still can’t find use intraoperative imaging neck US c FNA
don’t enter mediastinum during this first go

69
Q

if Alk phosp was high preop suspect bone hunger post operatively prior to a parathyroidectomy?

A

calcium supplementation and calcitriol usually restored in 24 hrs

70
Q

When to use cryopreservation of parathyroid gland?

A

Cryopreservation-
borderline cases where you only find 3 glands
normal gland and you missed or patient only has 3 glands
allows you to reimplant if you find in your studies no residual parathyroid tissue

71
Q

Initial steps when given a case that is Persistent Hyperparathyroidism from another surgeon?

A

Consider a tertiary center
review imaging, path, operative reports where was the RLN? labs
op report- exploration carotid sheath? thymectomy? exploration TE groove? exploration of other side of neck?
reexamine indications for surgery
reop there is risks injury to RLN, perm hypothyroidism
r/o other causes of hypercalcemia, meds, 24 hr urine to r/o BFHH

72
Q

W/U to perform when given a persistent hyperparathyroidism case?

A

Two test
U/S - evaluates superficial structures
perithyroid, intrathyroid tissue, thyroid nodules, carotid sheath down to mediastinum, c FNA (doesn’t evaluate deeper structures)
Sestamibi tech 99- evaluates deep structures
mediastinum, posterior to larynx, trachea, esophagus)
consider CTA
localize missing adenomas (adenomas will light up on arterial phase)
Selective venous scan - invasive

73
Q

What to do during the operation prior with persistent hyperparathyroidism?

A

Preop- laryngoscopy to document vocal cord dysfunction from unrecognized RLN injury
IO RLN monitoring
baseline PTH and calcium
suspected PT send for frozens r/o misidentification
IO PTH monitoring
failure for PTH to drop >50% after 10 minutes should prompt further exploration

74
Q

MC location missing parathyroid adenoma? Inferior and superior areas?

A

regular anatomical position
inferior PT glands typically 2 cm area around inferior pole
Superior PT glands typically 2cm superior to to RLN as crosses ITA
MC ectopic area INFERIOR is cervical thymus, ipsilateral thyroid lobe, carotid sheath, anterior mediastinum (inappropriate to search unless seen on preop imaging )
MC ectopic area SUPERIOR - path of superior pedicle deep along preverterbral fascia, TE groove (should mobilize trachea and esophagus to view retrolaryngeal and retropharyngeal gland)

75
Q

What to do with Multiglandular dz hyperparathyroid?

A

complete cervical exploration and excision of PT tissue and reimplant appx 30-40mg morsalized PT tissue into non dominant brachioradialis musce
cryopreservation- residual PT tissue should performed so when detectable hypoparathyroid is high then can reimplant PT tissue (which was histo proven)

76
Q

How do you get and how to treat Parathyromatosis?

A

Parathyromatosis (abnormal PT tissue surrounding contiguous structures 2/2 to previous surgery diffuse seeding)
complete excision of all identifiable PT implants including resection of involved strap m, thyroid lobe as well as ipsilateral central LN dissection

77
Q

Post op management and follow up of parathyroidectomy surgery?

A

F/U - 1-2 wks eval for hypocalcemia, vocal strenth
check calcium and PTH 6 months and yearly
if low then reimplant cryo preserve or activated 1,25 OH Vitamin D