haemophilia

Question 1

what is haemophilia?

Answer 1

a rare disorder in which blood does not clot normally because it lacks sufficient blood clotting proteins ( clotting factors)

CBC is usually normal

Question 2

causes:

Answer 2

1) genetic
2) acquired spontaneous mutation ( pregnant, cancer, autoimmune, allergic reaction to medications)

Question 3

what is the difference between haemophilia A, B, C.

Answer 3

a: VIII
B: IX
C: XI

A and B- are X linked recessive
C can be passed down to both females and males.

Question 4

what is PTT for

Answer 4

to measure VIII, IX, XI and XIII 7 9 11 13

Question 5

what is PT for

Answer 5

to measure I, II, V, VII, X
1 2 4 6 10

Question 6

what is fibrinogen for

Answer 6

I

Question 7

management of hemophilia

Answer 7

DDAVP ( desmopressin ) to stimulate factor VIII 7 release
self infusion at home,
replacement of clotting factor VIII IX from donated human blood or recombinant clotting factors.

Question 8

complications of hemophilia

Answer 8

deep internal bleeding
severe anemia
infection from frequent infusion
adverse reaction from clotting treatment