Haematology I

Question 1

How would you confirm a suspicion of aplastic anaemia?

Parietal cell antibody serology

Peripheral blood film

Haematinics

Lymph node biopsy

Bone marrow biopsy

Answer 1

How would you confirm a suspicion of aplastic anaemia?

Parietal cell antibody serology

Peripheral blood film

Haematinics

Lymph node biopsy

Bone marrow biopsy

Question 2

Diffuse large cell B-cell lymphoma causes which haemolytic pathology? [1]

Answer 2

Cold AIHA

Question 3

Cold AIHA is most commonly caused by [] antibodies.

IgA
IgG
IgD
IgM
IgE

Answer 3

Cold AIHA is most commonly caused by [] antibodies.

IgA
IgG
IgD
IgM
IgE

IgM fixes complement causing direct intravascular haemolysis.

Warm weather makes you feel IgGreat, Cold weather makes you feel IgMiserable

Question 4

What clotting study results would indicate DIC? [3]

Answer 4

Prolonged PT and APTT with low platelets point to DIC

Question 5

You perfom a blood film and find bite cells.
What is the likely diagnosis? [1]

Answer 5

Bite and blister cells are typical of the blood film in G6PD deficiency

Have a Bite of Heinz Fava beans.
=>
Bite cells. Heinz bodies. Fava beans.

Question 6

A 30-year-old man is investigated for enlarged, painless cervical lymph nodes. A biopsy is taken and a diagnosis of Hodgkin’s lymphoma is made. Which one of the following types of Hodgkin’s lymphoma carries the best prognosis?

Lymphocyte predominant
Mixed cellularity
Nodular sclerosing
Hairy cell
Lymphocyte depleted

Answer 6

A 30-year-old man is investigated for enlarged, painless cervical lymph nodes. A biopsy is taken and a diagnosis of Hodgkin’s lymphoma is made. Which one of the following types of Hodgkin’s lymphoma carries the best prognosis?

Lymphocyte predominant
Mixed cellularity
Nodular sclerosing
Hairy cell
Lymphocyte depleted

Question 7

[] gallstones are associated with sickle cell

Answer 7

Pigmented gallstones are associated with sickle cell